Poly(oxy-1,2-ethanediyl), α-[2-(dide- cylmethylammonio)ethyl]- .omega.- hydroxy-, propanoate (salt) (Bardap 26)

Long-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Endpoint:

long-term toxicity to aquatic invertebrates

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Justification for type of information:

The read across to Bardap 26 is supported by a set of bridging studies for DDAC and ADBAC demonstrating the similarity in physico-chemical, toxicological, ecotoxicological and movement and fate properties of these quaternary substances. The quaternary ammonium compound (Bardap 26) for which read across is requested, and the two substances used for read across (DDAC and ADBAC) belong to the family of cationic surfactants. Within this family they form a well-defined subgroup of substances with similar chemical structure; (1) one or two hydrophobic, non-branched alkyl chains with a main chain length distribution of C10-16, (2) one to three methyl group substituents and (3) a hydrophilic group carrying a positively charged quaternary nitrogen atom.

Reason / purpose for cross-reference:

read-across source

Duration:

21 d

Dose descriptor:

NOEC

Effect conc.:

0.018 mg/L

Nominal / measured:

meas. (initial)

Conc. based on:

test mat.

Basis for effect:

reproduction

Duration:

21 d

Dose descriptor:

LOEC

Effect conc.:

0.032 mg/L

Nominal / measured:

meas. (initial)

Conc. based on:

test mat.

Basis for effect:

reproduction

Key result

Duration:

21 d

Dose descriptor:

NOEC

Effect conc.:

0.01 mg/L

Nominal / measured:

meas. (initial)

Conc. based on:

test mat.

Basis for effect:

mortality

Remarks:

survival

Duration:

21 d

Dose descriptor:

LOEC

Effect conc.:

0.018 mg/L

Nominal / measured:

meas. (initial)

Conc. based on:

test mat.

Basis for effect:

mortality

Remarks:

survival

Duration:

21 d

Dose descriptor:

NOEC

Effect conc.:

0.018 mg/L

Nominal / measured:

meas. (initial)

Conc. based on:

test mat.

Basis for effect:

other: Condition

Duration:

21 d

Dose descriptor:

LOEC

Effect conc.:

0.032 mg/L

Nominal / measured:

meas. (initial)

Conc. based on:

test mat.

Basis for effect:

other: Condition

Duration:

21 d

Dose descriptor:

EC50

Effect conc.:

>= 0.018 - <= 0.056 mg/L

Nominal / measured:

meas. (initial)

Conc. based on:

test mat.

Basis for effect:

reproduction

Duration:

21 d

Dose descriptor:

LC50

Effect conc.:

0.023 mg/L

Nominal / measured:

meas. (initial)

Conc. based on:

test mat.

Basis for effect:

mortality

Remarks on result:

other: 0.0034 - 0.0057 mg/l

Description of key information

One key study is available to determine the long-term toxicity of Bardac 22 (read-across from structural analog, Didecyldimethylammonium Chloride) to Daphnia magna. The study was conducted in accordance with OECD Guideline 211 with no deviations and GLP compliant. The Daphnia were exposed to the test material at concentrations of 3.2, 5.6, 10, 18, 32 and 56 mg/L for 21 days. The NOEC and LOEC for reproductive effects were determined to be 0.018 mg/L and 0.032 mg/L, respectively. The NOEC and LOEC for survival effects were determined to be 0.010 mg/L and 0.018 mg/L, respectively and for condition, the NOEC and LOEC were determined

to be 0.018 mg/L and 0.032 mg/L, respectively.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates

Effect concentration:

0.01 mg/L

Additional information

In a study conducted in accordance with OECD Guideline 211, Daphnia magna were exposed to the test material, Bardac 22 with radiolabelled Didecyldimethylammonium Chloride for 21 days, at concentrations of 0, 0.0032, 0.0056, 0.010, 0.018, 0.032, 0.056 mg/l (actual test concentrations, 0, 0.0035, 0.0062, 0.0097, 0.0189, 0.0329, 0.0592 mg/l). The study was conducted in an intermittent flow through system which provided ca. 250 ml of test substance in dilution water every 51 minutes.  Four replicates of each concentration (3.2, 5.6, 10, 18, 32 and 56 mg/l) and control media were tested with 10 test animals (<24-hours old).  Under the conditions of this study, the NOEC and LOEC for reproductive effects were determined to be 0.018 mg/l and 0.032 mg/l, respectively. The NOEC and LOEC for survival effects were determined to be 0.010 mg/l and 0.018 mg/l, respectively and for condition, the NOEC and LOEC were determined to be 0.018 mg/l and 0.032 mg/l, respectively.