Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
sub-chronic toxicity: other route
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
supporting study
Study period:
1982
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Test procedure in accordance with generally accepted scientific standards and described in sufficient detail.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1982

Materials and methods

Principles of method if other than guideline:
Method: other: see text
GLP compliance:
yes

Test material

Constituent 1
Reference substance name:
Alcohols, C9-11
EC Number:
266-367-6
EC Name:
Alcohols, C9-11
Cas Number:
66455-17-2
IUPAC Name:
decan-1-ol
Details on test material:
C9-11 alcohols Cas# 66455-17-2 (Neodol 91) 84% linear monobranched at the 2 position

Test animals

Species:
rat
Strain:
Fischer 344
Sex:
male/female

Administration / exposure

Route of administration:
other: Atmosphere containing saturated vapour
Duration of treatment / exposure:
9-days over a 12-day period
Frequency of treatment:
6-hours/day
Doses / concentrations
Remarks:
Doses / Concentrations:
0.0 and 158 mg/m3
Control animals:
yes, concurrent no treatment
Details on study design:
Post-exposure period: None

Results and discussion

Effect levels

Dose descriptor:
NOAEL
Effect level:
> 0.158 other: mg/l
Sex:
male/female

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

There were no significant differences between test and control group for  any of the parameters evaluated. NOAEL 0.158 mg/l (saturated vapour  concentration).

Applicant's summary and conclusion