Registration Dossier

Administrative data

Endpoint:
sub-chronic toxicity: other route
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
supporting study
Study period:
1982
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Test procedure in accordance with generally accepted scientific standards and described in sufficient detail.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1982

Materials and methods

Principles of method if other than guideline:
Method: other: see text
GLP compliance:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
C9-11 alcohols Cas# 66455-17-2 (Neodol 91) 84% linear monobranched at the 2 position

Test animals

Species:
rat
Strain:
Fischer 344
Sex:
male/female

Administration / exposure

Route of administration:
other: Atmosphere containing saturated vapour
Duration of treatment / exposure:
9-days over a 12-day period
Frequency of treatment:
6-hours/day
Doses / concentrations
Remarks:
Doses / Concentrations:
0.0 and 158 mg/m3
Control animals:
yes, concurrent no treatment
Details on study design:
Post-exposure period: None

Results and discussion

Effect levels

Dose descriptor:
NOAEL
Effect level:
> 0.158 other: mg/l
Sex:
male/female

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

There were no significant differences between test and control group for  any of the parameters evaluated. NOAEL 0.158 mg/l (saturated vapour  concentration).

Applicant's summary and conclusion