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EC number: 475-900-3 | CAS number: -
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 30 May - 28 June 2005
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- The study was conducted according to an internationally recognised method, and under GLP. However, the test was not suitable for the substance, as unstable, and the determination could not be achieved. Moreover, the test item identification is incomplete (unspecified cis-trans isomery, therefore identified under the generic CAS 17129-06-5). Therefore validation applies with restrictions.
- Reason / purpose for cross-reference:
- reference to other study
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - Shake Flask Method)
- Version / remarks:
- Directive 92/69/EEC
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Certificate from 2004-12-22
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- gas chromatography
- Remarks on result:
- not determinable
- Remarks:
- not stable in octanol
- Executive summary:
The partition coefficient of the test substance was measured, under GLP, according to EU A.8 guideline, shake-flask method. The determination could not be achieved, because the test substance is not stable in n-octanol (and not in water either).
Reference
Description of key information
The study cannot be completed because the substance decomposes.
Key value for chemical safety assessment
Additional information
An attempt was made to determine the partition coefficient of the substance, in an experimental study, conducted according to EU guideline and GLP. The analysis revealed that the substance was not stable in octanol. Therefore the study could not be achieved.
QSAR determination of the logKow of the parent substance is not considered to be of scientific interest, since the substance decomposes, its bioaccumulation potential is not relevant.
Moreover, considering the substance is used as an intermediate under strictly controlled conditions, the information on the degradation products has little meaning too.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
