Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-830-0 | CAS number: 100-21-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Additional ecotoxological information
Administrative data
- Endpoint:
- additional ecotoxicological information
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 015
Materials and methods
Results and discussion
Applicant's summary and conclusion
- Executive summary:
The authors additionally reported outcomes for various aquatic ecotoxicology studies performed with PTA. A common feature to all tests was the use of dimethyl sulfoxide (DMSO) as a co-solvent, applied at a rate of 0.1% (v/v), i.e. 1.0 mL/L. It should be noted that this concentration is 10x higher than the maximum co-solvent concenttration (0.1 mL/L) recommended in various aquatic test guidelines. Few experimental details are reported in all cases.
D. magna: 21d chronic toxicity: Followed OECD TG 211 (2012), ten replicates with one parental daphnid each, treatments: 0 (control and DMSO control), 0.12, 0.38, 1.11, 3.33 and 10 mg PTA/L. Three medium renewals/week, water quality measured at each renewal. No analytical verification of exposure concentrations. Adult mortality and juvenile numbers recorded daily and parental body lengths measured at D21. Count data not reported. Significant reduction in juvenile production at 10 mg/L, not stated whether in relation to untreated or DMSO control, or mean of both. Intrinsic rate of population increase >1. Survival and reproductive NOECs were 10 and 3.3 mg PTA/L. M. macrocopa (sp. indigenous to Korea) 7d chronic toxicity: Followed published protocol, ten replicates with one parental animal each, with same range of treatments as for D. magna. Three medium renewals/week, water quality measured at each renewal. No analytical verification of exposure concentrations. Surviving adults and juvenile numbers were recorded daily.
Count data not reported. No significant difference indicated by ANOVA, but numbers of juveniles/adult were "significantly decreased" in a dose-response manner (beta = -0.217, r-squared = 0.789, p for trend = 0.006), not stated whether in relation to untreated or DMSO control. 7d survival and reproduction NOECs were 10 mg PTA/L. O. latipes 40d ELS test: Followed OECD TG 210 with unspecified "minor modification", 60 eggs per treatment at 0, 0.01, 0.1, 1.0 and 10 mg TPA/L, with 5 replicates per treatment. Report ambiguous as to whether DMSO co-solvent was used in this test.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
