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EC number: 202-830-0
CAS number: 100-21-0
Administration of terephthalic acid did not induce any increase in the
incidence of micronucleated PCEs in any of the treated groups.
Terephthalic acid was tested in the mouse micronucleus assay. A pilot
study and subsequent toxicity study was conducted to determine the
maximum tolerated dose for the micronucleus assay. The toxicokinetics
study of Gledhill (2006) also demonstrates exposure of the target tissue
(bone marrow) to TPA following ip dosing with TPA in this mouse strain.
Terephthalic acid was administered in corn oil by a single
intraperitoneal injection, at a constant injection volume of 20 ml/kg.
Based on mortality and clinical signs observed during the pilot and
toxicity studies, the maximum tolerated dose set for the micronucleus
study was 800 mg/kg bw. Clinical signs included lethargy, piloerection,
tremors and crusty eyes. In the micronucleus assay, terephthalic acid
was administered i.p. at doses of 0, 200, 400 and 800 mg/kg. Bone marrow
cells were harvested 24 or 48 hours later. The positive control was
cyclophosphamide. No significant increase in micronucleated
polychromatic erythrocytes in test article treated groups relative to
vehicle controls was observed.
Under the conditions of this study, was concluded to be negative in the
mouse micronucleus test.
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