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Toxicological information

Additional toxicological data

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Administrative data

additional toxicological information
Type of information:
experimental study
Adequacy of study:
supporting study
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Organisms and test systems used are not relevant for the purpose of the registration.

Data source

Reference Type:
Antibacterial action against Streptococcus mutans and inhibitory effect on the experimental hamster caries of condensed phosphates.
Shibata H
Bibliographic source:
Department of Preventive Dentistry, Faculty of Dentistry, Kyushu University, Fukuoka 812, Japan.

Materials and methods

Type of study / information:
STPP was tested for both the bacterial inhibition and the effect on hamster teeth,
The effects of condensed phosphates (CPs), widely used as food additives, on the growth and sugar metabolism of carcinogenic Streptococcus mutans (experiment 1) and experimental hamster caries induced by the bacterium (experiment 2), were studied.
Test guideline
no guideline available
Principles of method if other than guideline:
Experiment 1: Strep. mutans strains HS-6, BHT, Ingbritt, OMZ176, B14, OMZ175 and K1-R were used in disc diffusion assay on BHI agar.

Experiment 2: hamster were inoculated orally with strain K1-R and reared on the high-sucrose diet No. 2000 supplemented with 2% (w/w) CP for
60 days.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Pentasodium triphosphate
EC Number:
EC Name:
Pentasodium triphosphate
Cas Number:
Molecular formula:
pentasodium bis(phosphonatooxy)phosphinate
Details on test material:
All condensed phosphates used in the experiment were of food additive grade.

Results and discussion

Any other information on results incl. tables

Experiment 1:

It was revealed that food additive grade CPs has the same growth inhibitory effects as purified preparations of linear type, and that they were superior to the cyclic CPs. The growth inhibition by CP was reversed by divalent metal ions (Ca++, Mg++ or Mn++). It was suggested that the chelating capacity of CPs was responsible for their antibacterial actions. The antibacterial actions of CPs seemed largely bacteriostatic, but slight bactericidal activity was observed upon prolonged incubation.

Experiment 2:

CPs were found to inhibit caries development (P0.01) and plaque deposition (P0.05). The caries inhibitory effect of CPs was also clearly seen in each of the different molar teeth. It was suggested that the antibacterial actions of CPs were responsible for their caries inhibitory effects.

Applicant's summary and conclusion