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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Study performed to GLP and guideline.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1989
Report date:
1989

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Pentasodium triphosphate
EC Number:
231-838-7
EC Name:
Pentasodium triphosphate
Cas Number:
7758-29-4
Molecular formula:
H5O10P3.5Na
IUPAC Name:
pentasodium triphosphate
Details on test material:
- Name of test material (as cited in study report): Sodium Tripolyphosphate
- Physical state: White solid
- Lot/batch No.: B5885327c

Test animals

Species:
rabbit
Strain:
New Zealand White
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Hazleton Research Animals, Inc., Denver, Pennsylvania
- Age at study initiation: Young adult
- Weight at study initiation: 2.35 - 3.52 kg
- Housing: Individually housed in stainless steel cages
- Diet (e.g. ad libitum): Purina High Fiber Chow 5326 available ad libitum
- Water (e.g. ad libitum): Fresh tap water available ad libitum



ENVIRONMENTAL CONDITIONS
- Temperature (°F): 66 - 74
- Humidity (%): 28 - 39
- Photoperiod (hrs dark / hrs light): 12/12


Test system

Type of coverage:
semiocclusive
Preparation of test site:
shaved
Vehicle:
physiological saline
Controls:
no
Amount / concentration applied:
0.5 g
Duration of treatment / exposure:
4 h
Observation period:
30 min, 24, 48 and 72 hours
Number of animals:
3

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 4.5
Score:
0
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 24 h
Score:
0
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 48 h
Score:
0
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 72 h
Score:
0

Any other information on results incl. tables

No irritation was noted on any test site during the study and the test was terminated following the 72 hour scoring. All animals remained healthy throughout the study.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU