Registration Dossier

Administrative data

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
The substance is a UVCB. Standard tests for this endpoint are intended for single substances and are not appropriate for this complex substance. Therefore, the results presented are indicative of the potential solubility of this UVCB. For this reason the results should only be used as indicative and hence the reliability code assigned.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2010
Report Date:
2010

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
GLP compliance:
no
Remarks:
other quality assurance
Type of method:
flask method

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent

Results and discussion

Water solubility
Water solubility:
0.5 - 229 mg/L
Temp.:
20 °C
pH:
>= 8.36 - <= 8.42
Remarks on result:
other: The average water solubility of the constituents of the UVCB varies from 0.5 to 229 mg/L.
Details on results:
The constituent with the highest average solubility in the UVCB is calcium (229 mg/L). The average solubility of lead is 8 mg/L.
The solubility of Co, Cr, Cu, Fe and Ni is below 0.01 mg/L, the solubility of Ag, Al, As, Bi, Cd, Mn, Mo, Sb, Se, Sn and Te is below 0.02 mg/L.

Any other information on results incl. tables

Substances with solubility <10 mg/l are considered low-soluble and those with solubility <1 mg/l are considered poorly soluble. The standard method involves three tests, which is not enough to conduct a statistical analysis.

Preliminary test: 

0.1 g sample was not found to be soluble in the following volumes of water: 0.1 mL, 0.5 mL, 1 mL, 2 mL, 10 mL, 100 mL, 200 mL 

.

Flask test: Result are presented in Table 1.

Table 1 Water solubility after respectively 14. 15 and 16 days shaking and calculated average water solubility.

 

 

Shaking for

Shaking for

Shaking for

 

 

 

14 days

15 days

16 days

Average

 

Sample code

10TT04662

10TT04762

10TT04818

 

pH

 

8.36

8.41

8.42

 

ICP Ag

mg/l

<0.2

<0.2

<0.2

<0.2

ICP Al

mg/l

<0.2

<0.2

<0.2

<0.2

ICP As

mg/l

<0.2

<0.2

<0.2

<0.2

ICP B

mg/l

0.6

0.6

0.6

0.6

ICP Bi

mg/l

<0.2

<0.2

<0.2

<0.2

ICP Ca

mg/l

226

231

231

229

ICP Cd

mg/l

<0.2

<0.2

<0.2

<0.2

ICP Co

mg/l

<0.1

<0.1

<0.1

<0.1

ICP Cr

mg/l

<0.1

<0.1

<0.1

<0.1

ICP Cu

mg/l

<0.1

<0.1

<0.1

<0.1

ICP Fe

mg/l

<0.1

<0.1

<0.1

<0.1

ICP K

mg/l

3

3

3

3

ICP Mg

mg/l

1.59

1.6

1.61

1.6

ICP Mn

mg/l

<0.2

<0.2

<0.2

<0.2

ICP Mo

mg/l

<0.2

<0.2

<0.2

<0.2

ICP Na

mg/l

10.8

11

10.9

11

ICP Ni

mg/l

<0.1

<0.1

<0.1

<0.1

ICP Pb

mg/l

8

7.8

7.9

8

ICP S

mg/l

170

172

170

171

ICP Sb

mg/l

<0.2

<0.2

<0.2

<0.2

ICP Se

mg/l

<0.2

<0.2

<0.2

<0.2

ICP Si

mg/l

2.3

2.3

2.4

2.3

ICP Sn

mg/l

<0.2

<0.2

<0.2

<0.2

ICP Te

mg/l

<0.2

<0.2

<0.2

<0.2

ICP Zn

mg/l

0.6

0.63

0.35

0.5

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): slightly soluble (0.1-100 mg/L) major constituents
The water solubility test was done for one sample (10TT01254). According to the results of the water solubility test calcium is the most soluble constituent of the UVCB (229 mg/L). The average solubility of lead is 8 mg/L. However the test method is primarily used for individual substances and not for UVCBs. Therefore the results of the test must be used with caution.
Executive summary:

According to the results of the water solubility test calcium is the most soluble constituent of the UVCB (229 mg/L). The average solubility of lead is 8 mg/L. However the test method is primarily used for individual substances and not for UVCBs. Therefore the results of the test must be used with caution.