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Ecotoxicological information

Long-term toxicity to aquatic invertebrates

Administrative data

long-term toxicity to aquatic invertebrates
Type of information:
calculation (if not (Q)SAR)
Migrated phrase: estimated by calculation
Adequacy of study:
key study
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Automatic calculation with MeCLas tool
Cross-referenceopen allclose all
Reason / purpose:
reference to same study
Reason / purpose:
reference to other study

Data source

Reference Type:
other: software

Materials and methods

Principles of method if other than guideline:
Aquatic toxicity of the UVCB substance was determined by classifying based on Mixture rules from EU CLP ( tier 1= summation of classified components or Tier 2 = additivity of soluble components to derive Hazard class) and back calculation to the corresponding EC10/NOEC range

Test material

Details on test material:
Reasonable worst-case across industry, as reported in Section 1.2.
Representative sample for mineralogical information is provided in IUCLID Section 4.23.

Results and discussion

Effect concentrations
21 d
Dose descriptor:
Effect conc.:
<= 0.1 mg/L
Nominal / measured:
Conc. based on:
test mat.
Basis for effect:
other: most sensitive species
Details on results:
The substance is classified as chronic cat 1 to environment resulting in a EC10/NOEC < 0.01 mg/L (rapidly degradable UVCB) and < 0.1 mg/L (non-rapidly degradable UVCB). EC10/NOEC < 0.1 mg/L was selected since this covers both rapidly and non rapidly degradable UVCBs.

Any other information on results incl. tables

According to MeClas, the substance is classified as chronic 1 to environment.

Applicant's summary and conclusion

Validity criteria fulfilled:
Good quality estimate of the EC10/NOEC of the UVCB substance.
The substance is classified as chronic cat 1 to environment resulting in a EC10/NOEC <= 0.1 mg/L.
Executive summary:

The study provided a conservative estimate of the effect concentration, derived on basis of the classification outcome (mixture toxicity rules) from a reasonable worst-case sample of the substance using mineralogical information from the representative sample. 


Validity of the model used:

1. Defined endpoint: the endpoint is a REACH compliant defined endpoint

2. Unambiguous algorithm: EU CLP guidance based summation formula to determine classification, followed by back-calculation to related hazard criteria

3. Applicability domain: applicable to classify complex metal containing materials. 

4. Mechanistic interpretation - metal species: the tool translates the elemental composition into a mineralogical composition relevant for classification.