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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Study period:
09 - 19 Oct. 1990
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: GLP guideline study. Read-across to synthetic amorphous silica.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1991
Report Date:
1991

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Sident 9, >98% (SiO2), Na20 <1%, Al2O3 <0.2%, SO3 <0.8%, Fe2O3 <0.03%:
CAS-Name: Silica, precipitated, cryst.-free; CAS-No.: 112926-00-8
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Test animals

Species:
rabbit
Strain:
other: White Russian

Test system

Type of coverage:
occlusive
Preparation of test site:
shaved
Vehicle:
water
Controls:
no
Amount / concentration applied:
Dose: 0.5 g
Duration of treatment / exposure:
4 hour(s)
Observation period:
14 days
Number of animals:
3
Details on study design:
The substance (0.5 g) was moistened with 0.5 ml water and placed on a skin area of approx 6.25 cm2.

Results and discussion

In vivo

Results
Irritation parameter:
primary dermal irritation index (PDII)
Score:
0
Irritant / corrosive response data:
There were not any irritating effects.

Any other information on results incl. tables

No signs of irritation.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
No classification (EU and GHS)
Executive summary:

Jahn and Berthold (1991) studied skin irritation of precipitated silica by moistening the substance (0.5 g) with 0.5 ml water and placing on a skin area of approx 6.25 cm2. There were not any irritating effects.