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EC number: 237-523-0 | CAS number: 13825-74-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
According to REACH Regulation (EC) No. 1907/2006, Annex VII, column 2, and Guidance Chapter R7a, a study on skin irritation/corrosion and eye corrosion/irritation does not need to be conducted if the available information indicates that the criteria are met for classification as corrosive. Since titanium oxide sulphate releases sulphuric acid when in contact with wet materials, no testing required.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Titanium oxide sulphate is hydrolyses immediately when in contact with wet materials.
TiOSO4 + H2O↔TiO2 + H2SO4
The hydrolysis reaction proceeds when the resulting sulphuric acid is being neutralised. Therefore, under physiologically and environmentally relevant conditions titanium oxide sulphate hydrolyses rapidly according to above stated reaction to sulphuric acid and to titanium dioxide.
Skin and eye corrosion:
Sulphuric acid, which is produced as a product of hydrolysis, eventually accounts for the corrosive character of target chemical titanium oxide sulphate. Sulphuric acid≥ 15% is labelled as C; R35 under Directive 67/548/EEC, and as Skin corr. 1A, H314 "Causes severe skin burns and eye damage" under CLP, regulation 1272/2008.
No data available on respiratory irritation, however neither sulphuric acid nor titanium dioxide are noted to cause respiratory irritation effects.
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: corrosive
Effect level: empty Endpoint conclusion: Adverse effect observed
Justification for classification or non-classification
Discussions on skin corrosion classification:
According to the harmonised classification and labelling, Annex VI of Regulation 1272/2008 (016 -020 -00 -8), sulphuric acid is subject to harmonised classification as Skin Corr. 1A H314 if c(H2SO4) ≥ 15%. As sulphuric acids results from hydrolysis of target chemical titanium oxide sulphate in eqimolar amounts, classification as skin Corr. 1A H314 applies to titanium oxide sulphate solutions containing c(TiOSO4) ≥ 15%. In case 5%≤ c(TiOSO4) <15%, Skin irrit. 2 H315 and Eye irrit. 2 H319 would apply. No classification necessary if c(TiOSO4) < 5%.
No data available on respiratory irritation, however neither sulphuric acid nor titanium dioxide are noted to cause respiratory irritation effects.
Proposed classification and labelling for titanium oxide sulphate acc. to CLP Regulation 1272/2008 (classification based on the fact that sulphuric acid results in equimolar amounts from the hydrolysis of target chemical titanium oxide sulphate when getting in contact with wet materials):
Hazard class and code in case c(TiOSO4) = c(H2SO4) ≥ 15%:
Skin Corr. 1A, H314
Labelling: GHS05, Danger
Hazard class and code in case c(TiOSO4) = c(H2SO4) < 15% but ≥ 5 %
Skin Irrit. 2, H315
Labelling: GHS07, Warning
Proposed classification and labelling for titanium oxide sulphate according to Directive 67/548/EEC (classification based on the fact that sulphuric acid results in equimolar amounts from the hydrolysis of target chemical titanium oxide sulphate when getting in contact with wet materials):
Hazard class and code in case c(TiOSO4) = c(H2SO4) ≥ 15%:
Corrosive, R35
Labelling: C and R35
Hazard class and code in case c(TiOSO4) = c(H2SO4) < 15% but≥ 1 %:
Irritating, R38
Labelling: Xi and R38
Hydrolysis of titanium oxide sulphate produces sulphuric acid, which is sufficient to justify the classification of target chemical titanium oxide sulphate. This conclusion is confirmed by test results and by accidental human exposure.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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