Registration Dossier
Registration Dossier
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EC number: 218-216-0 | CAS number: 2082-79-3
Endpoint summary
Administrative data
Description of key information
Additional information
No toxic effects occur at the range of water solubility.
- For octadecyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate no toxic effects were observed in acute fish, daphnia and algae tests. Two static studies in fish according to OECD 203 showed no treatment related mortality. The 96-h LC50 for both species (Lepomis macrochirus, Salmo gairdneri) was >100 mg/l. Daphnia magna were exposed to the substance (dispersant used) during 24 hours in a static test (OECD 202). No effects on mobility were found at any of the concentrations tested (48-h EC50 is >100 mg/l). A 72h study with the algae Scenedesmus subspicatus showed no effect at the highest concentration tested (72-h ErC50 >30 mg/l nominal; growth rate).
- In a guideline study with activated sludge from a sewage treatment plant no inhibition of respiration was reported at a concentration of 100 mg/L octadecyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate. The 3-h EC50 was >100 mg/L. Therefore, the inhibition of the degradation activity of activated sludge is not anticipated when introduced in appropriate low concentrations.
- In a chronic daphnia test according to OECD 211 no effects occurred for reproduction of Daphnia magna. Based on the loading rate of the WAF the NOEL (21d) was >= 2 mg/L.
Assessment of major degradation product Metilox acid (CAS: 20170-32-5)
According to a data screening, the main metabolite, Metilox acid, is of moderate acute toxicity to Daphnia, not toxic to fish and not inhibitory to bacteria. These substances are supposed to be subject for REACh registration and thereby thoroughly assessed during this process.
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