Registration Dossier
Registration Dossier
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EC number: 218-216-0 | CAS number: 2082-79-3
Endpoint summary
Administrative data
Description of key information
Additional information
Based on a re-evaluation of an OECD 305C bioconcentration study with fish, octadecyl 3-(3,5-di-tert butyl-4-hydroxyphenyl)propionate has a BCF of < 210-1470 and hence a moderate to high bioaccumulation potential. Additionally, due to the fast primary degradation, bioaccumulation of the substance is not likely to occur in the environment. The main primary degradation product metilox acid has, based on experimental data, a BCF of 532 or lower and it has hence low to moderate bioaccumulation potential. The second primary degradation product, 1-octadecanol, has a high bioaccumulation potential based on its estimated logKow (7.72), but is not likely to be bioaccumulated in the environment due to its ready biodegradability.
Calculations of the BCF with standard QSARs (EPISuite 4.00) resulted in low BCF values (BCFBAF v3.00, regression based estimate: BCF = 5.77 L/kg; Arnot-Gobas method (including biotransformation rate estimates: BCF 0.8954 L/kg)). A calculated BAF value indicates similar low accumulation properties as suggested by BCF(BCFBAF v3.00, Arnot-Gobas method, including biotransformation rate estimates, upper trophic: BAF 2.975 L/kg). Furthermore, the maximum diameter is markedly above the OSIRIS cut-off criterion of 17Ä, with a diamax of 35.78 Ä (OASIS Catalogic v 5.10.6). Therefore, octadecyl 3-(3,5-di-tert butyl-4-hydroxyphenyl)propionate is unlikely to cross biological membranes and to accumulate to a significant extend in biota.
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