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Specific investigations: other studies

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Abstracts of specific studies which do not follow standard test procedures indicate:

  • Observations following the repeated administration of 2 -EH to rats and mice included increased liver weight, peroxisome proliferation, and changes (induction) of enzymes involved in Phase I and Phase II drug metabolism
  • 2 -EH is a peroxisome proliferator in rodents (rats and mice), but not in other species including humans. This effect is therefore not relevant for the assessment of human health effects.
  • 2 -EH is hepatotoxic. Impairment of the mitochondrial energy supply is the underlying toxic mechanism.
  • Degeneration of testes and Sertoli cells were not associated with 2 -EH, but with MEHP, which is generated following the administration of DEHP.
  • 2-EH administered to cells of mouse Leydig tumour cell line, MA-10, did not reveal any reduction of steroidogenic potential of the cells (no reduction of progesterone production or gene expression of key steroidogenic enzymes). Whereas DEHP, MEHP and 2-ethylhexanal significantly disrupt the steroidogenesis in MA-10 cells.
  • 2 -EH was found to have an impact on maternal-embryonic zinc metabolism (decrease of embryonic Zn uptake).