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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Due to the low vapour pressure, the technically highest attainable concentration is approximately 1.8 mg/m3 (0.29 ppm) when the test substance is evaporated at 20°C (concentration not determined), which is below any limit concentration.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1966
Report Date:
1966

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Principles of method if other than guideline:
Inhalation risk test
GLP compliance:
no
Test type:
other: Inhalation risk test
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Triethanolamine

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
other: unchanged (no vehicle)
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
8 h
Concentrations:
Saturated TEA atmosphere (concentration not given).
No. of animals per sex per dose:
6 males, 6 females
Control animals:
no
Details on study design:
- Duration of observation period following administration: 7 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC0
Effect level:
other: saturated TEA atmosphere (approximately 1.8 mg/m3)
Exp. duration:
8 h
Mortality:
0/12
Clinical signs:
no clinical signs reported
Body weight:
mean body weight gain: 17.25 g
Gross pathology:
1 chronic bronchitis, all other animals without findings

Applicant's summary and conclusion