Registration Dossier
Registration Dossier
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EC number: 200-877-1 | CAS number: 75-54-7
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
The most reliable study available was chosen as key study. Where there was more than one reliable study, the most recent study was selected. Where reliable studies were not available for the test substances, studies for an analogous substance were selected. The results of all the studies were in agreement.
Short description of key information:
In vitro:
Gene mutation (Bacterial reverse mutation assay / Ames test): negative with and without activation in all strains tested (equivalent to OECD TG 471)
Cytogenicity in mammalian cells: read-across from analogous substance CAS 75-78-5: negative in L5178Y mouse lymphoma cells (similar to OECD TG 473)
Mutagenicity in mammalian cells: read-across from analogous substance CAS 75-78-5: negative in L5178Y mouse lymphoma cells (similar to OECD TG 476)
In vivo: read-across from analogous substance CAS 75-78-5: negative in mouse micronucleus test (US EPA guideline test, similar to OECD TG 474)
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
The available information for the substance indicates that when tested in vitro, dichloro(methyl)silane (CAS number 75 -54 -7) did not induce mutations in bacteria. No data in mammalian cells is available for dichloro(methyl)silane. Data is, however, available for the related substance dichloro(dimethyl)silane (CAS number 75 -78 -5), which is considered a close structural analogue of dichloro(methyl)silane. Both substances have similar functional groups and hydrolyse rapidly in water to silanols . Dichloro(dimethyl)silane did not induce mutations in bacterial or mammalian cells, nor chromosome aberrations in mammalian cells. The conclusion reached from in vitro results is confirmed by the negative result obtained when dichloro(dimethyl)silane was tested in vivo in the mouse micronucleus assay. It is considered appropriate to read across the results for dichloro(dimethyl)silane to dichloro(methyl)silane. Therefore it is considered that classification for mutagenicity is not required.
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