Registration Dossier
Registration Dossier
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EC number: 200-877-1 | CAS number: 75-54-7
Endpoint summary
Administrative data
Description of key information
Dichloro(methyl)silane is accepted as being corrosive to skin (key study: BRRC, 1981) and, implicity, damaging to eyes. There are data to support this. Acute inhalation toxicity studies have shown that this substance is corrosive to the respiratory tract.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Two studies were available for skin irritation/corrosion, therefore the most reliable of these was selected as the key study. Both studies showed dichloro(methyl)silane to be corrosive to the skin. A further study showed this substance to be corrosive to eyes.
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: corrosive
Effect level: empty Endpoint conclusion: Adverse effect observed
Justification for classification or non-classification
Dichloro(methyl)silane is labelled 'R35 Causes severe burns' and 'R37 Irritating to respiratory system' under Directive 67/548/EEC. Based on a weight-of evidence the proposed labelling according to Regulation 1272/2008 is 'Skin Corr. 1A', and hence 'H314: Causes severe skin burns and eye damage', and 'EUH071: Corrosive to the respiratory tract'. The serious damage to eyes is implicit for substances classified as Category 1 for skin corrosion.
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