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Diss Factsheets
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EC number: 200-877-1 | CAS number: 75-54-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- No data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: 2e The study was well documented and meets generally accepted scientific principles, but was not conducted in compliance with GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- not specified
- Remarks:
- Although a GLP statement was not included with the report, it is known that Bushy Run Research Center (BRRC) operated as a GLP facility at the time the testing was conducted.
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Dichloro(methyl)silane
- EC Number:
- 200-877-1
- EC Name:
- Dichloro(methyl)silane
- Cas Number:
- 75-54-7
- Molecular formula:
- CH4Cl2Si
- IUPAC Name:
- dichloro(methyl)silane
- Details on test material:
- - Name of test material (as cited in study report): Organochlorosilane A-155
- Substance type: chlorosilane
- Physical state: clear yellow liquid
- Expiration date of the lot/batch: No data
- Stability under test conditions: No data
- Storage condition of test material: No data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - Weight at study initiation: 200 and 300 g
- Fasting period before study: overnight prior to dosing
No further details available
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: some undiluted, some in L-45 oil
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 8.0 ml/kg
- Doses:
- 0.25 (undiluted), 2.0 (males), 4.0, 5.7 (females), 8.0 (25% diluted in L-45 oil) ml/kg
- No. of animals per sex per dose:
- 5/sex/dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Weights were recorded immediately prior to dosing and on days 7 and/or 14 of the observation period.
- Necropsy of survivors performed: yes - Statistics:
- LD50s were calculated by the moving average method (Thompson, 1947) and were based on a 14-day observation period.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- < 0.25 mL/kg bw
- Remarks on result:
- other: undiluted
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 2.83 mL/kg bw
- 95% CL:
- >= 1.85 - <= 4.32
- Remarks on result:
- other: 25% solution in L-45 oil
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 4.73 mL/kg bw
- 95% CL:
- >= 4.05 - <= 5.53
- Remarks on result:
- other: 25% solution in L-45 oil
- Mortality:
- Undiluted: Dead/Dosed: Males: 4/5; Females: 5/5
25% oil solution: Males: 3/5, 4/5, and 0/5 at 8.0, 4.0, and 2.0 mL/kg bw
Females: 5/5, 5/5, and 0/5 at 8.0, 5.7, and 4.0 mL/kg bw - Clinical signs:
- other: Undiluted: Males: Death of 1 rat within 3.5 hours Females: Sluggishness at 3 hr 25% oil solution: Males: At 8.0 mL/kg bw:: Breathing difficulty at 2 min; death of 3 at 12 to 20 min. At 4.0 mL/kg bw:: Sluggishness at 10 min; death of 3 at 1.5 hr; survi
- Gross pathology:
- Undiluted: Males: In animals that died, livers dark; spleens enlarged; stomachs black; intestines red; adrenals red or black. In survivor, kidneys fluid-filled.
Females: In animals that died, Lungs dark red; livers black; stomachs black or red; kidneys dark; intestines blod-filled; adrenals red.
25% solution:
Males: At 8.0 mL/kg bw: In animals that died, stomachs distended, walls brittle, liquid-filled, glandular portions injected; livers brown-red; intestines brown with hardened areas; kidneys hard and brown; spleens enlarged. In survivors, nothing remarkable.
At 4.0 mL/kg bw: In animals that died, stomachs liquid-filled, injected, glandular portions black; livers dark near stomach; intestines red, injected; kidneys tan near stomach; spleens enlarged; pancreata red. In survivor, pancreatic lymph nodes enlarged; stomach adhered to liver and abdominal wall.
At 2.0 mL/kg bw: Nothing remarkable
Females: At 8.0 mL/kg bw: Stomachs liquid-filled, injected, glandular portions black; livers pale, hard in sections near stomach; intestines red, injected; kidneys tan, hard near stomach; spleens enlarged; pancreata tan.
At 5.7 mL/kg bw: Mucosal surface of stomachs smooth; livers mottled maroon, gray and brown; cortical surfaces of kidneys mottled maroon, gray and brown.
At 4.0 mL/kg bw: Nothing remarkable
Any other information on results incl. tables
Based on the results of this study, a subsequent study using a dilution of the test material was conducted.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In an acute oral toxicity study in rats (reliability score 2), which was comparable to OECD 401, the LD50 for undiluted organochlorosilane A-155 was less than 0.25 ml/kg bw. The LD50s for a 25% dilution of organochlorosilane in L-45 oil were 2.83 ml/kg bw and 4.73 for males and females, respectively.
- Executive summary:
In an acute oral toxicity study in Wistar rats (reliability score 2), which was comparable to OECD 401, the LD50 for undiluted organochlorosilane A-155 was less than 0.25 ml/kg bw. The LD50s for a 25% dilution of organochlorosilane in L-45 oil were 2.83 ml/kg bw and 4.73 for males and females, respectively. Following an oral gavage dose of undiluted test substance all animals died within 3.5 hours. All deaths following administration of diluted test substance occurred within two hours. Sluggishness was the main clinical sign of toxicty, but there were also some instances of dyspnea, unsteady gait and prostration. Gross necropsy mainly revealed discoloured, fluid-filled and/or enlarged organs (liver, spleen, intestines, stomach, kidneys).
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