Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 308-516-0 | CAS number: 98072-61-8
No information on animal testing of “Slimes and Sludges, precious metal refining" is available. “Slimes and Sludges, precious metal refining" 3 contains ≥ 1 % nickel chloride (specific concentration limits of nickel chloride; see "justification for classification and non-classification" below). Hence, “Slimes and Sludges, precious metal refining" 3 meets classification criteria for STOT RE 1 via the inhalation route.“Slimes and Sludges, precious metal refining" 4 contains ≥ 1 % nickel chloride and ≥ 0.3 % lead and lead compounds relevant for C&L of grade 4. For all constituents there are specific concentration limits (SCLs) given for STOT RE classification (see discussion). Based on the SCLs and the specific rules for mixtures of Regulation (EC) 1272/2008 “Slimes and Sludges, precious metal refining" 4 requires classification as STOT RE 1.
Substance specific information for the UVCB substance "Slimes and Sludges, precious metal refining"is not available for the endpoint "Repeated Dose Toxicity". In order to meet the requirements for Annex VII till Annex X of Regulation (EC) 1907/2006, read across information from any constituents being relevant needs to be included. Due to the high number of constituents and variability in C&L of these constituents it was decided to use the classification information from the individual constituents and to calculate the resulting classification by using the generic concentration limits of ingredients of the mixture classified as a specific target organ toxicant that trigger classification of the mixture and respective rules of Regulation (EC) 1272/2006 section 184.108.40.206 “Classification of mixtures when data are available for all components or only for some components of the mixture” with the MeClas tool. This approach has been presented and discussed with ECHA in several meetings.
In total, four different grades of "Slimes and Sludges, precious metal refining" (composition profile 1 - composition profile 4) were identified by the consortium that could be grouped according to their calculated C&L resulting from the specific composition profile. Thus, for "Slimes and Sludges, precious metal refining"two C&L entries for specific target organs toxicity (i.e., no C&L and STOT RE 1) were generated. Each group is described in a separate endpoint study record and endpoint summary.
Classification driver for STOT RE 1 are:
(i) Lead and lead compounds - oral (grade 4)
According to the self-classification of lead compounds thespecific concentration limits (SCL) for STOT RE classification are as follows:
STOT RE 1; H372: C ≥ 0.5%
STOT RE 2; H373: 0.05% ≤ C < 0.5%
(ii) Nickel dichloride – inhalation (grade 3 & 4)
According to the self-classification of nickel chloride the specific concentration limits (SCL) for STOT RE classification (inhalation) are as follows:
STOT RE 1; H372: C ≥ 1 %
STOT RE 2; H373: 1 % ≤ C < 7 %
Classification of UVCB substances as being toxic to specific target organs after repeated dose application is based on the presence of a constituent ≥ 1 % classified as STOT-RE 1 and of a constituent ≥ 10 % classified as STOT-RE 2, respectively. However, for lead compounds and nickel dichloride there are specific concentration limits given for STOT RE classification assigned by the lead/nickel industry. According to Regulation (EC) 1272/2008 “specific concentration limits” should take precedence over any other concentration limits for the purpose of classification.
The classification driver for STOT RE classification of “Slimes and Sludges, precious metal refining” 3 is nickel dichloride in concentration relevant for C&L as STOT RE 1. The classification drivers for STOT RE classification of “Slimes and Sludges, precious metal refining” 4 are nickel dichloride and lead and lead compounds in concentration relevant for C&L as STOT RE 1.
Hence, “Slimes and Sludges, precious metal refining” 3&4 meets classification criteria as STOT RE 1 and requires labelling with H372 (causes damage to organs).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again