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Key value for chemical safety assessment

Additional information

Substance specific information for the UVCB substance "Slimes and Sludges, precious metal refining" is not available for the endpoint "Genetic Toxicity". In order to meet the requirements for Annex VII till Annex X of Regulation (EC) 1907/2006, read across information from any constituents being relevant needs to be included. Due to the high number of constituents and variability in C&L of these constituents it was decided to use the classification information from the individual constituents and to calculate the resulting classification by using the “generic concentration limits of ingredients of a mixture classified as germ cell mutagens that trigger classification of the mixture.” and respective rules of Regulation (EC) 1272/2006 section 3.5.3.1 “Classification of mixtures when data are available for all ingredients or only for some ingredients of the mixture” with the MeClas tool. This approach has been presented and discussed with ECHA in several meetings.

In total, four different grades of "Slimes and Sludges, precious metal refining"(composition profile 1 - composition profile 4) were identified by the consortium that could be grouped according to their calculated C&L resulting from the specific composition profile. Thus, for "Slimes and Sludges, precious metal refining" three C&L entries for genetic toxicity (i.e., no C&L and mutagenicity 2 and 1B) were generated. Each group is described in a separate endpoint study record and endpoint summary.

Short description of key information:
No information on animal testing of "Slimes and Sludges, precious metal refining" is available. Since, "Slimes and Sludges, precious metal refining" (composition profile 1 - composition profile 2) neither contains any constituent ≥ 0.1 % classified as mutagen Muta. 1, nor any constituent ≥ 1 % classified as mutagen Muta. 2, the substance does not require classification for germ cell mutagenicity.

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

"Slimes and Sludges, precious metal refining" (composition profile 1 - composition profile 2) neither contains any constituent ≥ 0.1 % (w/w) classified as mutagen Muta. 1, nor any constituent ≥ 1 % (w/w) classified as mutagen Muta. 2. In conclusion,"Slimes and Sludges, precious metal refining" (composition profile 1 - composition profile 2) does not possess mutagenicity and/or genotoxicity in accordance with Regulation (EC) 1272/2008.