Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 308-516-0 | CAS number: 98072-61-8
No information on animal testing for skin and eye irritation of “Slimes and Sludges, precious metal refining” - composition profile 3 is available. The approach followed on C&L of UVCB substances as irritant or corrosive to skin and eye in case where data are available on the constituents, but not on the UVCB substance as a whole, is based on the theory of additivity (CLP guideline, section 126.96.36.199.3.2, November 2013). Hence, the UVCB substance “Slimes and Sludges, precious metal refining” - composition profile 3 meets classification criteria as Skin Irrit. 2 and has to be labelled with H315 (Causes skin irritation). Furthermore, ”Slimes and Sludges, precious metal refining” - composition profile 3 requires classification as Eye Irrit. 2 in accordance with Regulation (EC) 1272/2008 and requires labelling with H319 (Causes serious eye irritation).
Substance specific information for the UVCB substance of "Slimes and Sludges, precious metal refining" is not available for the endpoint "Irritation/Corrosion". In order to meet the requirements for Annex VII - Annex X of Regulation (EC) 1907/2006, read across information from any constituent being relevant needs to be included. Due to the high number of constituents and variability in C&L of these constituents it was decided to use the classification information from the individual constituents and to calculate the resulting classification by using the “theory of additivity" (Regulation (EC) No 1272/2008, section 3.2.3. and 3.3.3) with the MeClas tool. This approach has been presented and discussed with ECHA in several meetings.
In total, four different grades of "Slimes and Sludges, precious metal refining" (composition profile 1 - composition profile 4) were identified by the consortium that could be grouped according to their calculated C&L resulting from the specific composition profile. Thus, for "Slimes and Sludges, precious metal refining" three C&L entries for irritation/corrosion (i.e., no C&L, irritation and corrosion) were generated. Each group is described in a separate endpoint study record and endpoint summary.
Skin irritation: “Slimes and Sludges, precious metal refining” - composition profile 3 meets classification criteria for skin irritation Skin Irrit. (theory of additivity was applied) and requires labelling with H315 (causes skin irritation) as defined in Regulation (EC) 1272/2008.
Eye irritation: “Slimes and Sludges, precious metal refining” - composition profile 3 meets classification criteria for Eye Irrit. 2 (theory of additivity was applied) and requires labelling with H319 (causes severe eye irritation) as defined in Regulation (EC) 1272/2008.
The generic term respiratory tract irritation (RTI) covers two different effects: (i) sensory irritation and (ii) local cytotoxic effects. The classification is usually covered under the endpoint specific target organs toxicity- single exposure (endpoint IUCLID 7.2) and - repeated exposure (endpoint IUCLID 7.5). Please refer to the endpoint summaries on acute toxicity and repeated dose toxicity for further information.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again