Registration Dossier
Registration Dossier
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EC number: 919-164-8 | CAS number: -
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / bone marrow chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1982
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: According to basic scientific principles.
- Justification for type of information:
- A discussion and report on the read across strategy is given as an attachment in IUCLID Section 13.
Cross-reference
- Reason / purpose for cross-reference:
- read-across: supporting information
Reference
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / bone marrow chromosome aberration
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- 1982
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: According to basic scientific principles.
- Justification for type of information:
- A discussion and report on the read across strategy is given as an attachment in IUCLID Section 13.
- Reason / purpose for cross-reference:
- read-across source
- Sex:
- not specified
- Genotoxicity:
- negative
- Toxicity:
- no effects
- Vehicle controls validity:
- valid
- Negative controls validity:
- not applicable
- Positive controls validity:
- not applicable
- Conclusions:
- Interpretation of results: negative
Stoddard Solvent did not induce significant chromosomal abnormalities. - Executive summary:
This data is being read across from the source study that tested Stoddard solvent based on analogue read across.
Stoddard Solvent did not induce significant chromosomal abnormalities.
Data source
Reference
- Reference Type:
- publication
- Title:
- Proceedings of the Symposium, The toxicology of petroleum hydrocarbons
- Author:
- Conaway, C.C., Schreiner, C.A., Cragg, S.T.
- Year:
- 1 982
- Bibliographic source:
- The American Petroleum Institute
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 475 (Mammalian Bone Marrow Chromosome Aberration Test)
- GLP compliance:
- not specified
- Type of assay:
- chromosome aberration assay
Test material
- Reference substance name:
- Stoddard solvent
- EC Number:
- 232-489-3
- EC Name:
- Stoddard solvent
- Cas Number:
- 8052-41-3
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- DMSO
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 0.087, 0.289, 0.868 mL/kg DMSO
Basis:
nominal conc.
- Control animals:
- yes, concurrent vehicle
Results and discussion
Test results
- Sex:
- not specified
- Genotoxicity:
- negative
- Toxicity:
- no effects
- Vehicle controls validity:
- valid
- Negative controls validity:
- not applicable
- Positive controls validity:
- not applicable
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results: negative
Stoddard Solvent did not induce significant chromosomal abnormalities. - Executive summary:
Stoddard Solvent did not induce significant chromosomal abnormalities.
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