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Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation
Remarks:
other: QSAR using the OECD Tooolbox
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: QSAR, no experimental study.
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
other: QSAR
Title:
Unnamed
Year:
2010
Report Date:
2010

Materials and methods

Principles of method if other than guideline:
not applicable
GLP compliance:
no
Type of study:
other: QSAR using the OECD Tooolbox

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

In vivo (LLNA)

Results
Remarks on result:
no indication of skin sensitisation based on QSAR/QSPR prediction

Any other information on results incl. tables

The OECD Toolbox application, which was used to to evaluate sensitisation QSAR considerations, did not indicate a sensisation potential. Acetamide (CAS 60-35-5) and N,N-dimethylformamide (CAS 68-12-2) were identified as related substances, and negative experimental data is available for both of these. OECD SIDS documents for N,N-dimethylformamide (CAS 68-12-2) are publicly available.

Applicant's summary and conclusion

Interpretation of results:
not sensitising
Remarks:
Migrated information
Executive summary:

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