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Toxicological information

Repeated dose toxicity: other routes

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Administrative data

Endpoint:
sub-chronic toxicity: other route
Adequacy of study:
other information
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Summary report: no detailed information, secondary literature; route of application not relevant for humans.

Data source

Reference
Reference Type:
publication
Title:
Etude toxicologique de la formamide et de ses dérivés N-Méthylés et N-Ethylés.
Author:
Chanh PH, Xuong ND, Azum-Gelade M-C
Year:
1971
Bibliographic source:
Thérapie 26, 409-424.

Materials and methods

Principles of method if other than guideline:
Method: other: according to Caujolle, F. et al.: Arzneimittelforschung 20: 1242-1246
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
TS-Freetext:
formamide; no data on purity of the compound

Test animals

Species:
rat
Strain:
Wistar
Sex:
male

Administration / exposure

Route of administration:
intraperitoneal
Duration of treatment / exposure:
7 weeks
Frequency of treatment:
once daily, 5 d/wk
Doses / concentrations
Remarks:
Doses / Concentrations:
150 mg/kg
Control animals:
yes, concurrent vehicle
Details on study design:
Post-exposure period: 24 h

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

RS-Freetext:
Depression of body weight gain, leukocytosis, elevated SGOT
and SGPT in blood. No microscopic histological changes in
various tissues.

Applicant's summary and conclusion