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EC number: 211-776-7 | CAS number: 694-83-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The compounds from the amine heads category are soluble and caustic in aqueous solution. This last feature was critical in the study design of available reports and data.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 1 825 mg/L
Additional information
For the amine heads category, four studies in regard to acute fish toxicity are available, covering 2 species and following similar experimental design (equivalent to OECD 203, static, no analytical monitoring). Only 2 studies however take into account the caustic properties of the category members.
The study on HMD performed by Munk (1992, No. 10F0733/9905156; supporting, RL 2) demonstrates that lethality due to alkaline pH occurs if not adjusted to the recommended range (6.5-8.5): A LC50 (96 h, Leuciscus idus) of 62.17 mg/L was determined without prior pH-adjustment of test solutions whereas the corresponding LC50 in case of pH-adaption was above the highest tested concentration of 215 mg/L and no lethality was observed.
In agreement with the above results, the study performed by Stahl & Hall (1985, No. HL-439-85) with fathead minnow and HMD resulted in a LC50(96 h) of 1825 mg/L (95%IC = 1237-2461 mg/L; Probit analysis). Very high concentrations up to 10 000 mg/L were tested and pH of the stock solution was adjusted to pH 8-8.5. Despite the lack of chemical analysis and the fact that the study was performed under static conditions, this is considered the key study (RL 2) for fish as it is the only study in which a LC50 was determined at reasonable conditions of pH. Moreover, test solutions of HMD have been shown to be completely stable under environmentally relevant conditions in a recent study on algae.
In two further studies rated not reliable performed by NATEC with DCH (NA 96 9410/1.3) and MPMD (NA 96 9410/2.3) on Leuciscus idus melanotus (only 48 hours exposure period) obviously pH was not adjusted. This resulted in LC50(48 h)-values of 200 mg/L (DCH) and 130 mg/L (MPMD). As DCH is the least caustic member of the amine heads category, the observed effect concentrations without pH-adjustment fit very well to the physicochemical properties of the members.
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