Cyclohex-1,2-ylenediamine

Short-term toxicity to fish

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to fish

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Justification for type of information:

For details on endpoint specific justification please see read-across report in section 13 or find a link in cross-reference “assessment report”.

Reason / purpose for cross-reference:

assessment report

Reason / purpose for cross-reference:

read-across source

Test type:

static

Reference substance (positive control):

no

Key result

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

1 825 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Remarks on result:

other: 95% confidence interval: 1237 to 2461 mg/L

Duration:

96 h

Dose descriptor:

NOEC

Effect conc.:

1 000 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Duration:

96 h

Dose descriptor:

LOEC

Effect conc.:

1 800 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Details on results:

Due to the very similar molecular weight of source and target substance, the effect concentrations for the source substance are also valid for the target substance without further adjustment.

Validity criteria fulfilled:

yes

Remarks:

According to OECD 203 adopted July 1992

Conclusions:

Based on nominal concentrations of the source substance 1,6-hexane diamine (HMD; CAS No. 124-09-4), the LC50 (96 h) for fish (Pimephales promelas) determined in a study equivalent to OECD 203 with adaptation of pH is 1825 mg/L (95% CI: 1237-2461), with no effect observed at 1000 mg/L. Because of the very similar molecular weight of source and target substance, this directly applies to the target substance DCH.

Executive summary:

The study used as source investigated the acute toxicity to freshwater fish (Pimephales promelas). The study results of the source compound were considered applicable to the target compound and were used for classification and labelling acc. to REGULATION (EC) No 1272/2008. Justification and applicability of the read-across approach (structural analogue) is outlined in the read-across report in section 13 or find a link in cross reference “assessment report”.

Description of key information

Based on nominal concentrations of the source substance 1,6-hexane diamine (HMD; CAS No. 124-09-4), the LC50 (96 h) for fish (Pimephales promelas) determined in a study equivalent to OECD 203 with adaptation of pH is 1825 mg/L (95% CI: 1237-2461), with no effect observed at 1000 mg/L. Because of the very similar molecular weight of source and target substance, this directly applies to the target substance DCH.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish

Dose descriptor:

LC50

Remarks:

96 h

Effect concentration:

1 825 mg/L

Additional information

The study used as source investigated the acute toxicity to freshwater fish (Pimephales promelas). The study results of the source compound were considered applicable to the target compound and were used for classification and labelling acc. to REGULATION (EC) No 1272/2008. Justification and applicability of the read-across approach (structural analogue) is outlined in the read-across report in section 13.