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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Justification for type of information:
Please see cross reference attachments shown below
Cross-referenceopen allclose all
Reason / purpose for cross-reference:
read-across source
Reference
Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable study with basic documentation which meets basic scientific principles and contains sufficient detail to be able to judge the results reliable as a contribution to the understanding of the toxicity of this substance.
Principles of method if other than guideline:
Method according to (unspecified) French regulations of 1971 which are in turn derived from the method of Draize (1959). The Draize method is the origin of the OECD test method.
GLP compliance:
not specified
Species:
rabbit
Strain:
other: New Zealand (unspecified)
Type of coverage:
not specified
Preparation of test site:
other: both intact and abraded skin areas exposed
Vehicle:
not specified
Number of animals:
6
Irritation parameter:
primary dermal irritation index (PDII)
Basis:
mean
Time point:
other: 24 hours
Score:
0.17
Max. score:
8
Reversibility:
fully reversible within: 72 hours
Irritant / corrosive response data:
Four out of the 6 rabbits showed very slight erythema (grade 1) at 24 hours. There was full recovery by 72 hours.

A primary skin irritation index of 5 or more is considered a positive response.

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Executive summary:

In an in vivo skin irritation study in which basic details are available, 2 -butoxyethyl acetate produced only very slight irritation in some of the exposed rabbits which was fully reversed within 72 hours. The response did not meet the threshold for classification as a skin irritant. This result is considered representative of the skin irritation potential of 2 -(2 -butoxyethoxy)ethyl acetate.

Synopsis

Not irritating.

Reason / purpose for cross-reference:
read-across: supporting information

Data source

Materials and methods

Test material

Constituent 1
Chemical structure
Reference substance name:
2-(2-butoxyethoxy)ethyl acetate
EC Number:
204-685-9
EC Name:
2-(2-butoxyethoxy)ethyl acetate
Cas Number:
124-17-4
Molecular formula:
C10H20O4
IUPAC Name:
2-(2-butoxyethoxy)ethyl acetate
Details on test material:
- Name of test material (as cited in study report): Butyldiglycolacetat, 2-(2-butoxyethoxy)ethyl acetate
- Physical state: colourless liquid
- Analytical purity: 98,4 mass%
- Lot/batch No.: Beh. 6

Results and discussion

In vivo

Results
Remarks on result:
probability of weak irritation

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met