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Toxicological information

Developmental toxicity / teratogenicity

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Administrative data

Endpoint:
developmental toxicity
Type of information:
experimental study
Adequacy of study:
key study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1988
Report date:
1988

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 414 (Prenatal Developmental Toxicity Study)
Limit test:
no

Test material

Test animals

Species:
rat
Strain:
other:

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure (if applicable):
whole body

Results and discussion

Results: maternal animals

Effect levels (maternal animals)

Dose descriptor:
LOEC
Effect level:
3 200 ppm (nominal)
Basis for effect level:
body weight and weight gain
clinical signs
early or late resorptions
food consumption and compound intake
water consumption and compound intake
Remarks on result:
other:

Maternal abnormalities

Key result
Abnormalities:
no effects observed

Results (fetuses)

Effect levels (fetuses)

Key result
Dose descriptor:
NOAEC
Effect level:
8 000 ppm (nominal)
Based on:
test mat.
Basis for effect level:
fetal/pup body weight changes
changes in litter size and weights
Remarks on result:
other:

Fetal abnormalities

Key result
Abnormalities:
effects observed, treatment-related
Localisation:
visceral/soft tissue: hepatobiliary
visceral/soft tissue: cardiovascular

Overall developmental toxicity

Developmental effects observed:
yes
Lowest effective dose / conc.:
20 000 ppm (nominal)
Treatment related:
yes
Relation to maternal toxicity:
developmental effects as a secondary non-specific consequence of maternal toxicity effects
Dose response relationship:
yes

Applicant's summary and conclusion