Registration Dossier
Registration Dossier
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EC number: 404-080-1 | CAS number: 1717-00-6 1,1-DICHLORO-1-FLUOROTHANE; BLOWTEM 141B; DEMEON 141B; GENESOLV 2000 (PURE); GENESOLV 2004 (IN MIXTURE); GENETRON (R) 141B; HCFC 141B; HFA 141B; SOLKANE 141B
Toxicity to reproduction
Administrative data
- Endpoint:
- two-generation reproductive toxicity
- Type of information:
- experimental study
- Adequacy of study:
- key study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EPA OTS 798.4700 (Reproduction and Fertility Effects)
- Qualifier:
- according to guideline
- Guideline:
- other:
- Limit test:
- no
Test material
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other:
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure (if applicable):
- whole body
Results and discussion
Results: P0 (first parental generation)
Effect levels (P0)
open allclose all
- Dose descriptor:
- NOAEC
- Effect level:
- 8 000 ppm (nominal)
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- body weight and weight gain
- water consumption and compound intake
- Remarks on result:
- other:
- Dose descriptor:
- NOAEC
- Effect level:
- 8 000 ppm (nominal)
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- reproductive performance
Target system / organ toxicity (P0)
- Key result
- Critical effects observed:
- no
Results: P1 (second parental generation)
Effect levels (P1)
- Dose descriptor:
- NOAEC
- Effect level:
- 20 000 ppm (nominal)
- Based on:
- test mat.
- Sex:
- male/female
- Remarks on result:
- not determinable due to absence of adverse toxic effects
Target system / organ toxicity (P1)
- Key result
- Critical effects observed:
- no
Results: F1 generation
Effect levels (F1)
- Key result
- Dose descriptor:
- NOAEC
- Generation:
- F1
- Effect level:
- 8 000 ppm (nominal)
- Based on:
- test mat.
- Sex:
- male
- Basis for effect level:
- sexual maturation
- body weight and weight gain
- organ weights and organ / body weight ratios
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
