Registration Dossier

Environmental fate & pathways

Endpoint summary

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Description of key information

The registrant considers it justified to omit the bioaccumulation study for this endpoint based on a lack of environmental exposure. However, in order to allow the CHESAR software to function correctly an indicative value of Log BCF = 3.031 has been used in the Chemical Safety Assessment. Given the limitations of the predictive software the registrant considers that this result must be regarded with some caution.

MMT[EHTG] is not anticipated to accumulate in organisms.

Additional information

There are no experimental results on bioaccumulation of MMT[EHTG] available. The Log BCF of MMT[EHTG] has been estimated by the BCFBAF v3.01 sub-model resident within EPIWEB v4.1 as 3.031.   

Similarly, employing the Base-line BCF model (Dimitrov et al., 2005) the estimated log BCFmax and log BCFcorr values were determined for MMT[EHTG] and equalled 1.61 and 0.97 respectively.  The BCFcorr value derived using the Base-line BCF model is indicative of a low potential for bioaccumulation of the molecule. 

Taken together, the BCFBAF and Base-line BCF models are indicative of a low potential for bioaccumulation of MMT[EHTG].

Terrestrial exposures are not anticipated. MMT[EHTG] has a low potential for bioaccumulation.

MMT[EHTG] does not accumulate in organisms.

Predictions made using the above-mentioned models rely on the Log Kow as predicted by EPISUITE, which is considered to be higher than the experimetally determined value and thus indicative of a worst case scenario.