N-[3-(dimethylamino)propyl]stearamide

Short-term toxicity to fish

Administrative data

Endpoint:

short-term toxicity to fish

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1990-08-28-1990-09-01

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1990

Report date:

1990

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 203 (Fish, Acute Toxicity Test)

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

N-[3-(dimethylamino)propyl]stearamide

EC Number:

231-609-1

EC Name:

N-[3-(dimethylamino)propyl]stearamide

Cas Number:

7651-02-7

Molecular formula:

C23H48N2O

IUPAC Name:

N-[3-(dimethylamino)propyl]octadecanamide

Test material form:

solid: pellets

Details on test material:

- Name of test material (as cited in study report): Stearylamidopropyl dimethylamine

Specific details on test material used for the study:

Details on properties of test surrogate or analogue material (migrated information):
Identity of test material confirmed

Sampling and analysis

Analytical monitoring:

no

Test solutions

Vehicle:

yes

Details on test solutions:

Tween 80

Test organisms

Test organisms (species):

Oncorhynchus mykiss (previous name: Salmo gairdneri)

Details on test organisms:

Supplier: Parkwood Trout farm, Kent, UK
Fish length: 4.8 +/- 0.2 cm
Fish weight: 1.56 +/- 0.2 g
Number of fish: 2 per concentration and in control

Study design

Test type:

static

Water media type:

freshwater

Limit test:

yes

Total exposure duration:

96 d

Test conditions

Hardness:

Dechlorinated water with ca. 50 mg/L CaCO3

Test temperature:

14 +/- 1 degree C

pH:

not given

Dissolved oxygen:

not given

Salinity:

not applicable

Nominal and measured concentrations:

Range finding: 0.1-1-10 mg/L
Definitive study: 0.1 mg/L

Details on test conditions:

Observation on moratlity: 24, 48, 72 and 96h
no mortality observed in the control and the lowest concentration tested of 0.1 mg/L

Reference substance (positive control):

not specified

Results and discussion

Effect concentrations

Effect concentrations 1

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

> 0.1 - < 1 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Remarks on result:

other: from range finding & definitive test

Effect concentrations 2

Duration:

96 h

Dose descriptor:

LC0

Effect conc.:

0.1 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Details on results:

not given

Applicant's summary and conclusion

Validity criteria fulfilled:

yes

Remarks:

toxicity range available

Conclusions:

In a acute fish test with rainbow trout no mortality was observed at the limit test concentration of 0.1 mg/L. In a range finding test also at 0.1 mg/L no mortality was observed but at 1 mg/L 100% mortality occured.This means the LC50 (96h) is in the range of 0.1 and 1 mg/L. This result is regarded as sufficent as a chronic fish test result with a NOEC of 0.1 mg/L is available (see IUCLID Chapter 6.1.2).