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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
other:

Data source

Reference
Reference Type:
publication
Title:
Acute toxicity of fluoride compound
Author:
Simons P., Pierron A.
Year:
1937
Bibliographic source:
Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Acute dermal toxicity in frogs
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
other: Frogs
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
other: Frogs were introduced in solutions of disodium hexafluorosilicate
Vehicle:
water
Details on dermal exposure:
No data
Duration of exposure:
No data
Doses:
No data
No. of animals per sex per dose:
No data
Control animals:
not specified

Results and discussion

Effect levels
Dose descriptor:
LDLo
Effect level:
ca. 448 mg/kg bw

Applicant's summary and conclusion