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Registration Dossier
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EC number: 240-934-8 | CAS number: 16893-85-9
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Mutagenicity of cosmetics ingredients licensed by European Communities
- Author:
- Gocke E, King MT, Eckhardt K, Wild D. Mutat
- Year:
- 1 981
- Bibliographic source:
- Mutation Research, 90, (1981),
Materials and methods
Test guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Disodium hexafluorosilicate
- EC Number:
- 240-934-8
- EC Name:
- Disodium hexafluorosilicate
- Cas Number:
- 16893-85-9
- Molecular formula:
- F6Si.2Na
- IUPAC Name:
- disodium hexafluorosilicate
Constituent 1
Method
- Target gene:
- No data
Species / strain
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Additional strain / cell type characteristics:
- not specified
- Metabolic activation:
- with and without
- Test concentrations with justification for top dose:
- Concentrations up to 3600 g/plate
- Vehicle / solvent:
- Water
Results and discussion
Test results
- Species / strain:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
Disodium hexafluorosilicate was negative with and without metabolic activation in an Ames test performed according to OECD 471 using the following strains: Salmonella typhimurium TA 98, TA100, TA1535, TA1537 (concentrations up to 3600 g/plate, -S9)
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