Registration Dossier
Registration Dossier
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EC number: 240-934-8 | CAS number: 16893-85-9
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Evaluation of the cutaneous irritation potential of 56 compounds
- Author:
- Guillot J.P., Gonnet J.F., Clement C.
- Year:
- 1 982
- Bibliographic source:
- Food and Chemical Toxicology, 20
Materials and methods
- Principles of method if other than guideline:
- According to OECD 404
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Disodium hexafluorosilicate
- EC Number:
- 240-934-8
- EC Name:
- Disodium hexafluorosilicate
- Cas Number:
- 16893-85-9
- Molecular formula:
- F6Si.2Na
- IUPAC Name:
- disodium hexafluorosilicate
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: New Zeland strain
- Details on test animals or test system and environmental conditions:
- No data
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- other: The substance was applied in ganze pads
- Controls:
- no
- Amount / concentration applied:
- Animals were exposed to 0.5 g of the substance for 4 hours.
- Duration of treatment / exposure:
- 4 h
- Observation period:
- 1, 24, 48, 72 h
- Number of animals:
- 6
Results and discussion
In vivo
Results
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 2
- Score:
- ca. 0.04
- Reversibility:
- fully reversible within: 24h
- Irritant / corrosive response data:
- Disodium hexafluorosilicate does not show irritating effects.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- After 14 days no signs of irritation on skin were evident. Thus, this substance cannot be classified as irritating.
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