Registration Dossier
Registration Dossier
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EC number: 204-873-0 | CAS number: 127-95-7
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
The information regarding the potassium hydrogen oxalate has been provided by read-across from oxalic acid. Short description of key information on bioaccumulation potential result:
Absorption:
- high recovery in urine and faeces
Distribution:
- small amounts found in various tissues (bone, skin, liver, viscera, muscle, kidney, heart and lungs)
- steady state distribution volume: 56.7 mL/100 g
Excretion:
- mainly excreted via urine and faeces
Toxicokinetic parameters:
- half-life of elimination: 0.3 ± 0.06 h
Key value for chemical safety assessment
Additional information
Oxalic acid is mainly excreted via urine and faeces, and has a very short half-life (0.3±0.06 h). Recovery is high, indicating a high absorption. Small amounts of oxalic acid can be found in various tissues (bone, skin, liver, viscera, muscle, kidney, heart and lungs). The steady state distribution volume of oxalic acid is 56.7 mL/100 g bw.
Discussion on bioaccumulation potential result:
Three studies on toxicokinetics of oxalic acid are included in the dossier, which are summarized in the following table.
Study reference |
Absorption (%) |
Distribution (%) |
Excretion (%) |
Toxicokinetic parameters |
Reliability |
NON KEY_1979_lit_Bannwart (oral gavage) |
recovery: 98.6 urine: 25.2 faeces:73.4 |
no data |
urine: 25.2 faeces:73.4 |
no data |
2 |
NON KEY_1978_lit_Hodgkinson (oral via feed/intraperitoneal) |
urine and faeces: 72.9 body tissue: 4.7 |
Bone: 3.37 Skin: 0.50 Liver: 0.33 Viscera: 0.27 Muscle: 0.13 Kidney: 0.01 Heart and lungs: 0.01 |
urine: 63.8 faeces: 9.10 |
No data |
2 |
NON KEY_1993_lit_Sugimoto (intravenous) |
urine: 83-90 faeces: 2.7 |
Steady state distribution volume: 56.7 mL/100 g bw |
urine: 83-90 faeces: 2.7 |
Half-life of elimination is 0.3±0.06 h |
2 |
Oxalic acid is mainly excreted via urine and faeces, and has a very short half-life (0.3±0.06 h). Recovery is high, indicating a high absorption. Small amounts of oxalic acid can be found in various tissues (bone, skin, liver, viscera, muscle, kidney, heart and lungs). The steady state distribution volume of oxalic acid is 56.7 mL/100 g bw.
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