1-aminopropan-2-ol

Acute Toxicity: other routes

Administrative data

Endpoint:

acute toxicity: other routes

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1965

Report date:

1965

Materials and methods

Principles of method if other than guideline:

BASF-Test

GLP compliance:

no

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

1-aminopropan-2-ol

EC Number:

201-162-7

EC Name:

1-aminopropan-2-ol

Cas Number:

78-96-6

Molecular formula:

C3H9NO

IUPAC Name:

1-aminopropan-2-ol

Test animals

Species:

mouse

Strain:

other: Kisslegg-mice

Sex:

male/female

Administration / exposure

Route of administration:

intraperitoneal

Vehicle:

water

Doses:

50, 100, 160, 200, 250, 320, 400, 1600 µl/kg
(48, 97, 155, 194, 243, 310, 388, 1552 mg/kg)

No. of animals per sex per dose:

5

Control animals:

not specified

Details on study design:

- Animals were observed over a 14 day period after administration of the test article

Results and discussion

Effect levels

Effect levels 1

Sex:

male/female

Dose descriptor:

LD50

Effect level:

ca. 184 mg/kg bw

Remarks on result:

other: after 14 days of observation

Effect levels 2

Sex:

male/female

Dose descriptor:

LD50

Effect level:

ca. 194 mg/kg bw

Remarks on result:

other: after 14 days of observation

Mortality:

1600 µl/kg: all animals died within 1h.
400 µl/kg: 4 males and 5 females died within 24 h and 1 male within 48h.
320 µl/kg: 1 male and 3 females died within 24 h, 1 male and 1 female within 48 h and 3 males and 1 female within 7 days.
250 µl/kg: 1 male and 1 female died within 48 h, 2 males and 2 females within 7 days and 1 female between 7 and 14 days.
200 µl/kg: 4 males and 2 females died between 48 h and 7 days.
160 µl/kg: 1 female died within 48 h and 1 female within 7 days.
50 and 100 µl/kg: no mortality occured.

Clinical signs:

1600 µl/kg:
Immediately post application slight spasms and after 2 min tonic convulsions, gaunted sides, irregular decelerated and intermittent respiration, hobbled gait, cry of pain, stretching and bending in convulsions.

400 and 200 µl/kg:
Immediately post application hobbled gait, gaunted sides, irregular accelerated and intermittent respiration, flattened ears, in short intervals spasmic convulsions, squatting posture, tremor, stagger.
3 h after application: very calm attitude, abdominal position, gaunted sides, apathy, hypothermia.
3 days after application: very calm attitude, irregular accelerated intermittent respiration, ruffled fur, squatted posture, crusted eyelid.
4 days after application: irregular respiration, ruffled fur.
5 days after application: very calm attitude, squatted posture, ruffled fur.
day 6 - sacrifice: ruffled fur.

160, 250 and 320 µl/kg:
Immediately post application slight spasms and after 2 min tonic convulsions, high stepping gait, stagger, gaunted sides, bending in convulsions, irregular accelerated respiration, flattened ears.
1.5 h after application: very calm attitude, gaunted sides, ruffled fur, stretching.
48 h after application: very calm attitude, ruffled fur, squatting posture, irregular respiration, crusted eyelids.
3 days after application: calm attitude, ruffled fur.
6 days after application: squatting posture, ruffled fur, irregular respiration, crusted eyelids,
7 days after application: ruffled fur, squatting posture, hypothermia, irregular respiration, gaunted sides, eyes closed.
9 days after application: calm attitude, gaunted sides.

100 µl/kg:
Squatting posture, hobbled gait, accelerated intermittent respiration, gaunted sides, calm attitude, stagger, eyes closed.
24 h after application: calm attitude, slight stagger, stretching, ruffled fur, irregular slightly accelerated respiration.
48 h - sacrifice: ruffled fur.

50 µl/kg:
Immediately post application accelerated respiration.

Gross pathology:

Histopathology data only for some animals available.
Dying animals: 3 animals showed agglutination of the abdominal cavity.
Sacrificed animals: 7 animals showed agglutination of the abdominal cavity and 5 animals swelling of the liver.

Any other information on results incl. tables

Table 1: Results of the i.p. experiment

Dose (µl/kg)	Conc.(%)	dead within 1h	dead within 1 day	dead within 2 days	dead within 7 days	dead within 14 days
1600	20	10/10	10/10	10/10	10/10	10/10
400	2	0/10	9/10	10/10	10/10	10/10
320	2	0/10	4/10	6/10	10/10	10/10
250	2	0/10	0/10	2/10	6/10	7/10
200	2	0/10	0/10	0/10	6/10	6/10
160	2	0/10	0/10	1/10	2/10	2/10
100	2	0/10	0/10	0/10	0/10	0/10
50	0.5	0/10	0/10	0/10	0/10	0/10