Registration Dossier
Registration Dossier
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EC number: 201-162-7 | CAS number: 78-96-6
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- The exposure period is longer than required by the guideline. This can be regarded as a worst-case scenario.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Monoisopropanolamine: acute toxicological properties and industrial handling hazards / HET K-5066-(4)
- Author:
- The Dow Chemical Company
- Year:
- 1 981
- Bibliographic source:
- Cited in: American Chemistry Council Amines Panel ICCA Iuclid Data Set, Nov. 22, 2002
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- no
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- 1-aminopropan-2-ol
- EC Number:
- 201-162-7
- EC Name:
- 1-aminopropan-2-ol
- Cas Number:
- 78-96-6
- Molecular formula:
- C3H9NO
- IUPAC Name:
- 1-aminopropan-2-ol
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- No data
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Duration of exposure:
- 6 h
- Concentrations:
- Nominal concentration 1126 ppm (3460 mg/m3)
- No. of animals per sex per dose:
- 6
- Details on study design:
- - 14-day observation period
- Examinations: mortality, clinical signs, body weight (frequency not indicated); macroscopy
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- > 3 460 mg/m³ air
- Exp. duration:
- 6 h
- Mortality:
- no mortality occurred
- Clinical signs:
- other: no adverse effects
- Body weight:
- no treatment related effects
- Gross pathology:
- slightly enlarged livers (2/6)
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LC50 is > 1126 ppm (3460 mg/m3) under these test conditions.
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