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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
The exposure period is longer than required by the guideline. This can be regarded as a worst-case scenario.

Data source

Reference
Reference Type:
review article or handbook
Title:
Monoisopropanolamine: acute toxicological properties and industrial handling hazards / HET K-5066-(4)
Author:
The Dow Chemical Company
Year:
1981
Bibliographic source:
Cited in: American Chemistry Council Amines Panel ICCA Iuclid Data Set, Nov. 22, 2002

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
GLP compliance:
no
Test type:
acute toxic class method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
1-aminopropan-2-ol
EC Number:
201-162-7
EC Name:
1-aminopropan-2-ol
Cas Number:
78-96-6
Molecular formula:
C3H9NO
IUPAC Name:
1-aminopropan-2-ol

Test animals

Species:
rat
Strain:
Fischer 344
Sex:
male
Details on test animals or test system and environmental conditions:
No data

Administration / exposure

Route of administration:
inhalation: aerosol
Duration of exposure:
6 h
Concentrations:
Nominal concentration 1126 ppm (3460 mg/m3)
No. of animals per sex per dose:
6
Details on study design:
- 14-day observation period
- Examinations: mortality, clinical signs, body weight (frequency not indicated); macroscopy

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LC50
Effect level:
> 3 460 mg/m³ air
Exp. duration:
6 h
Mortality:
no mortality occurred
Clinical signs:
other: no adverse effects
Body weight:
no treatment related effects
Gross pathology:
slightly enlarged livers (2/6)

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The LC50 is > 1126 ppm (3460 mg/m3) under these test conditions.