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EC number: 201-162-7 | CAS number: 78-96-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 3.6 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 25
- Dose descriptor starting point:
- NOAEL
- Value:
- 56 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 89 mg/m³
- Explanation for the modification of the dose descriptor starting point:
No inhalation repeated dose toxicity study is available. Thus, extrapolation from a OECD 408 oral study with DIPA is performed: NOAEL = 100 mg/kg bw/d. Correction of the NOAEL DIPA to the NOAEL MIPA based on the molecular weights: 100 mg/kg bw/d * (75.11 g/mol / 133.19 g/mol) = 56 mg/kg bw/d.
Based on the REACH R.8 guidance an inhalation volume for rats of 0.38 m3/kg for 8 hr exposure is used. NOAEL to NOAEC conversion: NOAEC rats = 56 mg/kg/d / 0.38 m3/kg = 147 mg/m3.
No oral absorption data are available for MIPA; hence data of DIPA are used (90% oral absorption). 100% absorption is assumed for inhalation: NOAEC rats = 147 mg/m3 x 90/100 = 133 mg/m3. Correction factor for increased inhalation volume during work: NOAEC worker, 8hr = 6.7 m3/ 10m3 x 132 mg/m3 = 89 mg/m3.
- AF for dose response relationship:
- 1
- Justification:
- The NOAEL is reliable. No adjustment is required.
- AF for differences in duration of exposure:
- 2
- Justification:
- Extrapolation to chronic exposure based on a sub-chronic toxicity study.
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- No allometric scaling has to be applied in case of oral to inhalation route to route extrapolation.
(already handled in the correction of the NOAEL) - AF for other interspecies differences:
- 2.5
- Justification:
- Default assessment factor.
- AF for intraspecies differences:
- 5
- Justification:
- Default assessment factor.
- AF for the quality of the whole database:
- 1
- Justification:
- The key study was conducted according to modern regulatory standards and was adequately reported. On this basis the quality of the database is not considered to contribute uncertainty and it is therefore not necessary to apply an additional factor.
- AF for remaining uncertainties:
- 1
- Justification:
- No remaining uncertainties.
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
Acute/short term exposure
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
Acute/short term exposure
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
Additional information - workers
Long-term – inhalation, systemic effects
Supporting the DNEL derivation with the structurally similar DIPA, a 28d repeated dose toxicity study based on hydrochloride salt of MIPA (CAS 7780 -04 -3, OECD 422 study) in rats is available. The derived DNEL value is 4.3 mg/m3 which is in line with the derived value above of 3.6 mg/m3.
NOAEL: 300 mg/kg bw/day; Systemic toxicity of the test substance for the F0 parental males based on some indications for a mild anemic process.
An 8 h respiratory volume of 0.38 m3/kg bw for rats was used for conversion into NOAEL upon inhalation exposure. Correction for activity driven differences of respiratory volumes in workers compared to workers in rest: 6.7 m3/10 m3. No oral absorption data are available for MIPA; hence, data of DIPA are used (90% oral absorption). 100% absorption is assumed for inhalation.
Modification of starting point: 0.38 m3/kg bw x 6.7 m3/10 m3 x 90/100. Correction for MW (75.1/111.6) between MIPA and the hydrochloride salt of MIPA.
Modified dose-descriptor: 300 x 6.7 x 90 x 75.1/ (0.38 x 10 x 100 x 111.6) = 320 mg/m3
Assessment factors:
- Interspecies (other): 2.5 (No allometric scaling has to be applied in case of oral to inhalation route to route extrapolation.)
- Intraspecies: 5 (Default assessment factor)
- Exposure duration: 6 (Default assessment factor for e sub-acute to chronic duration of the study.)
- Dose response: 1
- Quality of database: 1
DNEL-Value: 320 mg/m3 / (2.5 x 5 x 6 x 1 x 1) = 4.3 mg/m3
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.76 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 200
- Dose descriptor starting point:
- NOAEL
- Value:
- 300 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 169 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
NOAEL (90d, oral, DIPA) = 300 mg/kg bw/d; correction for MW (75.1/133.19) between MIPA and DIPA --> modified stating point: 300 x 75.1 / 133.19 = 169 mg/kg bw/day
- AF for dose response relationship:
- 1
- Justification:
- The NOAEL is reliable. No adjustment is required.
- AF for differences in duration of exposure:
- 2
- Justification:
- Default sub-chronic to chronic factor 2
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- The standard interspecies factor for rats is 4.
- AF for other interspecies differences:
- 2.5
- Justification:
- The factor for other interspecies differences, i.e. toxicokinetic/-dynamic differences.
- AF for intraspecies differences:
- 10
- Justification:
- Default assessment factor for the general population.
- AF for the quality of the whole database:
- 1
- Justification:
- The key study was conducted according to modern regulatory standards and was adequately reported. On this basis the quality of the database is not considered to contribute uncertainty and it is therefore not necessary to apply an additional factor.
- AF for remaining uncertainties:
- 1
- Justification:
- No remaining unvertainties.
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
Additional information - General Population
Although there are no consumer uses for MIPA, CAS 78-96-6, the systemic long-term oral DNEL for the general population might be necessary for an assessment of indirect exposure of humans via the environment (ECHA GD R.16, v 3.0, Feb 2016).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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