Registration Dossier

Toxicological information

Endpoint summary

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Administrative data

Key value for chemical safety assessment

Genetic toxicity in vivo

Description of key information

Toluene has been examined for genotoxicity both in vitro and in vivo in a range of assays and has shown negative results. It is concluded that the available data are sufficient and indicate that low benzene naphtha streams have no significant genotoxicity.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (negative)

Additional information

Additional information from genetic toxicity in vivo:


Justification for selection of genetic toxicity endpoint
Information available for the key marker substance toluene indicate no significant genotoxicity in vitro or in vivo.

Justification for classification or non-classification

It is concluded that the available data on the specific component toluene is sufficient for assessment and that no classification is warranted.