Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

  • EC / List name: Solvent naphtha (petroleum), heavy arom.
  • IUPAC name:
  • Other names
EC / List no.:
265-198-5
CAS no.:
64742-94-5
Index number:
649-424-00-3
Molecular formula:
SMILES:
*
InChI:
Type of substance:
UVCB
Origin:
Organic, Petroleum product
Registered compositions:
36
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the harmonised classification and labelling (CLP00) approved by the European Union, this substance may be fatal if swallowed and enters airways.

Additionally, the classification provided by companies to ECHA in REACH registrations identifies that this substance is very toxic to aquatic life with long lasting effects, may cause genetic defects, may cause cancer, causes damage to organs through prolonged or repeated exposure, is very toxic to aquatic life, is a flammable liquid and vapour, is suspected of damaging fertility or the unborn child, is harmful if swallowed, causes serious eye irritation, is harmful if inhaled, is suspected of causing cancer, causes skin irritation, may cause drowsiness or dizziness and may cause respiratory irritation.

Additionally, the classification provided by companies to ECHA in CLP notifications identifies that this substance is toxic to aquatic life with long lasting effects.

Breakdown of all 2905 C&L notifications submitted to ECHA

Asp. Tox. 1 H304 Harmonised Classification
Aquatic Chronic 2 H411
Flam. Liq. 3 H226
Eye Irrit. 2 H319
STOT SE 3 H336
Skin Irrit. 2 H315
Carc. 2 H351
STOT SE 3 H335
Acute Tox. 4 H302
Muta. 1B H340
Carc. 1B H350
Aquatic Chronic 1 H410
STOT RE 2 H373
Carc. 1A H350
Repr. 2 H361
https://echa.europa.eu/diss-blank-theme/images/cnl/graph/more.png 0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

At least one notifier has indicated that an impurity or an additive present in the substance impacts the notified classification.

Properties of concern

  • C
  • M

Regulatory activities

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 29 active registrations under REACH, 5 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Notification:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is manufactured and/or imported in the European Economic Area in 100 000+ tonnes per year.

This substance is used by consumers, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: lubricants and greases, adhesives and sealants, fuels, polishes and waxes, coating products and anti-freeze products.

Other release to the environment of this substance is likely to occur from: indoor use as processing aid, outdoor use as processing aid, indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

ECHA has no public registered data on the types of manufacture using this substance.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, non-industrial spraying, roller or brushing applications, treatment of articles by dipping and pouring and batch processing in synthesis or formulation with opportunity for exposure.

Other release to the environment of this substance is likely to occur from: outdoor use, indoor use as processing aid, indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).

This substance is used in the following products: fuels and oil and gas exploration or production products.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure, transfer of substance into small containers, laboratory work, production of mixtures or articles by tabletting, compression, extrusion or pelletisation and mixing in open batch processes.

Release to the environment of this substance can occur from industrial use: formulation of mixtures, manufacturing of the substance, formulation in materials, in processing aids at industrial sites, in the production of articles, as an intermediate step in further manufacturing of another substance (use of intermediates), as processing aid, for thermoplastic manufacture, as processing aid and of substances in closed systems with minimal release.

This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following areas: formulation of mixtures and/or re-packaging. This substance is used for the manufacture of: chemicals.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure, laboratory work and transfer of substance into small containers.

Release to the environment of this substance can occur from industrial use: of substances in closed systems with minimal release, in processing aids at industrial sites, as an intermediate step in further manufacturing of another substance (use of intermediates), for thermoplastic manufacture, as processing aid, as processing aid and in the production of articles.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, laboratory work and batch processing in synthesis or formulation with opportunity for exposure.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance, in processing aids at industrial sites, as processing aid, formulation of mixtures, formulation in materials, in the production of articles, as an intermediate step in further manufacturing of another substance (use of intermediates), as processing aid, for thermoplastic manufacture and of substances in closed systems with minimal release.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

General statements

Keep out of reach of children.

Prevention statements

When handling this substance: do not handle until all safety precautions have been read and understood; take actions to prevent static discharges; do not breathe the dust, fume, gas, mist, vapours or spray; keep away from heat, sparks, open flames and/or hot surfaces – No smoking; avoid release to the environment; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier.

Response statements

In case of incident: If swallowed: immediately call a poison center or doctor/physician. Get medical advice/attention if you feel unwell. If skin irritation occurs: Get medical advice/attention. If on skin (or hair): take off immediately all contaminated clothing. Rinse skin with water or shower. Collect spillage. If in eyes: rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing. Do not induce vomiting. If on skin: wash with soap and water.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • BASF SE, Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein Rheinland-Pfalz Germany
  • Chematek s.p.a., Piazzale Libia, 1 20135 Milano Lombardia Italy
  • Chemical Inspection & Regulation Service Limited, Room 002, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Room 002, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • COMPANÍA ESPAÑOLA DE PETRÓLEOS, S.A.U. (CEPSA), Torre Cepsa, Paseo de la Castellana 259A 28046 Madrid Spain
  • CRAY VALLEY SA, 2 Place Jean Millier 92400 Courbevoie France
  • Dow Belgium B.V.B.A., Sneeuwbeslaan 20, bus 10 2610 Wilrijik Belgium Belgium
  • DOW BENELUX B.V., Postbus 48 4530 AA Terneuzen Netherlands
  • DOW CHEMICAL COMPANY LTD, Diamond House, Lotus Park Kingsbury Crescent Middx UB7 0DQ Staines Middx United Kingdom
  • Haltermann Carless UK Limited, Grove House Guildford Road KT22 9DF Leatherhead Surrey United Kingdom
  • Henkel Global Supply Chain B.V., Gustav Mahlerlaan 2970 1081 LA Amsterdam Netherlands
  • John Hogg Technical Solutions Ltd, Mellors Road Trafford Park M17 1PB Manchester United Kingdom
  • L' ARCA S.r.l., via s.andrea 38/b 56029 Santa Croce Sull'Arno PISA Italy
  • Milliken Europe B.V.B.A., Ham 18-24 9000 Gent Belgium
  • Natson Ltd (Sila Chemicals Dalian Limited), 6 Prospect Way, Royal Oak Industrial Estate,Daventry NN11 8PL Northamptonshire United Kingdom
  • Nouryon Surface Chemistry AB, Stenunge Allé 3 - S-44485 Stenungsund - Sweden
  • REACHLaw Ltd., Vänrikinkuja 3 JK 21 02600 Espoo Finland
  • RÜTGERS Germany GmbH, Kekulestr. 30 44579 Castrop-Rauxel Germany
  • Shell Deutschland Oil GmbH, Suhrenkamp 71-77, 22335 Hamburg Germany
  • Sustainability Support Services (Europe) AB, Markaskälsvägen 6 22647 Lund Sweden
  • TÜV SÜD Iberia S.A.U. (008), Ronda Can Fatjó 13 08290 Cerdanyola del Vallès Spain
  • TÜV SÜD Iberia S.A.U. (033), Ronda Can Fatjó 13 08290 Cerdanyola del Vallès Barcelona Spain
  • TÜV SÜD Industrie Service GmbH, IS-USR-MUC Westendstraße 199 80686 Munich Germany
  • TÜV SÜD Industrie Service GmbH, Westendstraße 199 80686 München Germany
  • UAB "Mida LT", Gamyklos st. 19 LT-96155 Gargzdai Klaipedos distr. Lithuania
  • UMICORE Galvanotechnik GmbH, 53-79 Klarenbergstrasse 73525 Schwäbisch Gmünd Germany
  • versalis S.p.A., P.zza Boldrini 1 20097 San Donato Milanese MILANO Italy
  • ExxonMobil Petroleum & Chemical, BVBA, Polderdijkweg 2030 Antwerpen Belgium
  • SABIC UK Petrochemicals Limited, Wilton Centre TS10 4RF Redcar Cleveland United Kingdom
  • SARPOM S.r.l., Viale Castello della Magliana 25 00148 Roma Italy
  • Total Petrochemicals France SA, Immeuble Le Linéa 1, rue du Général Leclerc 92047 Paris La Défence Cedex France
  • Toyota Tsusho Europe S.A., Belgicastraat 13 1930 Zaventem Belgium

Other names

  • (EZ)-(RS)-2-{1-[(2E)-3-chloroallyloxyimino]propyl}-3-hydroxy-5-perhydropyran-4-ylcyclohex-2-en-1-one
  • -
  • 22403_64742-94-5
  • aromatic hydrocarbons C9-C12
  • aromatic naphta solvent
  • As the substance is a UVCB, there is no IUPAC name.
  • Benzene
  • C9-oil
  • Heavy aromatic solvent naphtha (Petroleum)
  • n/av
  • naphta, heavy aromatic
  • Naphtha (petroleum), heavy aromatic
  • NAPHTHA, PETROLEUM, HEAVY AROMATIC
  • Not applicable for a UVCB
  • not available
  • petroleum product
  • Reaction mass of 108-67-8 and 91-20-3 and 95-63-6
  • solvant naphta lourds
  • Solvent
  • Solvent Naphta
  • Solvent naphta (petroleum), heavy arom
  • Solvent naphta (petroleum), heavy arom.
  • Solvent naphta (petroleum), heavy aromatic
  • solvent naphta heavy aromatic
  • Solvent Naphtha
  • Solvent naphtha (petroleum)
  • Solvent naphtha (petroleum), heavy arom
  • Solvent naphtha (petroleum), heavy arom.
  • Solvent naphtha (petroleum), heavy arom. (C>5% aromatics)
  • SOLVENT NAPHTHA (PETROLEUM), HEAVY AROM. (R66-67)
  • Solvent naphtha (petroleum), heavy arom. Kerosine — unspecified; [A complex combination of hydrocarbons obtained from distillation of aromatic streams. It consists predominantly of aromatic hydrocarbons having carbon numbers predominantly in the range of C9 through C16 and boiling in the range of approximately 165 oC to 290 oC (330oF to 554oF).]
  • Solvent naphtha (petroleum), heavy arom.# Kerosine - unspecified
  • Solvent naphtha (petroleum), heavy arom.;
  • Solvent naphtha (petroleum), heavy arom.; A complex combination of hydrocarbons obtained from distillation of aromatic streams. It consists predominantly of aromatic hydrocarbons having carbon numbers predominantly in the range of C9 through C16 and boiling in the range of approximately 165 oC to 290 oC
  • Solvent naphtha (petroleum), heavy arom.; Kerosine
  • Solvent naphtha (petroleum), heavy arom.; Kerosine - unspecified
  • Solvent naphtha (petroleum), heavy arom.; Kerosine - unspecified;
  • Solvent naphtha (petroleum), heavy arom.; Kerosine - unspecified[A complex combination of hydrocarbons obtained from distillation of aromatic streams. It consists predominantly of aromatic hydrocarbons having carbon numbers predominantly in the range of C9 through C16 and boiling in the range of approximately 165 oC to 290 oC (330 oF to 554 oF).]
  • Solvent naphtha (petroleum), heavy arom.; Kerosine — unspecified; [A complex combination of hydrocarbons obtained from distillation of aromatic streams. It consists predominantly of aromatic hydrocarbons having carbon numbers predominantly in the range of C9 through C16 and boiling in the range of approximately 165 oC to 290 oC (330oF to 554oF).]
  • Solvent naphtha (petroleum), heavy arom.; kerosine-unspecified
  • SOLVENT NAPHTHA (PETROLEUM), HEAVY AROMATIC
  • Solvent naphtha (petroleum), heavy aromomatic
  • solvent naphtha (petroleum), highly arom.
  • Solvent naphtha (petroleum), light arom.
  • Solvent naphtha heavy aromatic
  • Solvent naphtha petroleum, heavy aromatic
  • Solvent naphtha(petroleum), heavy arom.
  • Solvent naphtha, heavy, arom.
  • Solvent naphtha, petroleum, heavy arom.
  • Solvent naptha (petroleum), heavy arom.
  • solventní nafta (ropná), těžká aromatická
  • UVCB substance
  • [
  • [A complex combination of hydrocarbons obtained from distillation of aromatic streams. It consists predominantly of aromatic hydrocarbons having carbon numbers predominantly in the range
  • [A complex combination of hydrocarbons obtained from distillation of aromatic streams. It consists predominantly of aromatic hydrocarbons having carbon numbers predominantly in the range ...
  • Solvent naphtha (petroleum), heavy arom.
  • Solvent naphtha (petroleum), heavy arom. (A complex combination of hydrocarbons obtained from distillation of aromatic streams. It consists predominantly of aromatic hydrocarbons having carbon numbers predominantly in the range of C9 through C16 and boiling in the range of approximately 165°C to 290°C (330°F to 554°F).)
  • Solvent naphtha (petroleum), heavy arom.; Kerosine - unspecified (A complex combination of hydrocarbons obtained from distillation of aromatic streams. It consists predominantly of aromatic hydrocarbons having carbon numbers predominantly in the range of C9 through C16 and boiling in the range of approximately 165°C to 290°C (330°F to 554°F).)
  • [A complex combination of hydrocarbons obtained from distillation of aromatic streams. It consists predominantly of aromatic hydrocarbons having carbon numbers predominantly in the range of C9 through C16 and boiling in the range of approximately 165 °C to 290 °C (330 °F to 554 °F).] (A complex combination of hydrocarbons obtained from distillation of aromatic streams. It consists predominantly of aromatic hydrocarbons having carbon numbers predominantly in the range of C9 through C16 and boiling in the range of approximately 165°C to 290°C (330°F to 554°F).)
  • Fioul retour
  • huile fluxante
  • Novasolve
  • Petrinex T9
  • Residu HEN
  • UNIAROM(R) TX 200ND DA

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 40 studies submitted
  • 40 studies processed
C Physical state at 20°C and 1013 hPa
Liquid (98%) [40]
C Form
Other (57%), Viscous (24%), Not specified (14%), Crystalline (5%) [21]
C Odour
Characteristic of aromatic compounds (60%), Other (30%), Pungent (7%) [30]
C Substance type
Organic (47%), Petroleum product (47%), Other (6%) [32]

Type of Study provided
Studies with data
Key study 31 9
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 4 summaries submitted
  • 3 summaries processed
Physical state at 20°C and 1013 hPa
Liquid (100%)

Melting/freezing point

Study results
  • 18 studies submitted
  • 13 studies processed
R Melting / freezing point
-100 - 53 °C @ 101.3 kPa [14]

Type of Study provided
Studies with data
Key study 14
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
R Summaries
  • 8 summaries submitted
  • 3 summaries processed
Melting / freezing point at 101 325 Pa
4.8 - 32.2 °C

Boiling point

Study results
  • 46 studies submitted
  • 37 studies processed
R Boiling point
25 - 430.5 °C @ 99.2 - 101.325 kPa [38]

Type of Study provided
Studies with data
Key study 41 3
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 8 summaries submitted
  • 3 summaries processed
Boiling point at 101 325 Pa
80.09 - 182 °C

Density

Study results
  • 31 studies submitted
  • 12 studies processed
R Density
0.77 - 0.85 g/cm³ @ 15 °C [2]
R Relative density
0.69 - 1.11 @ 15.556 - 20 °C [10]

Type of Study provided
Studies with data
Key study 29
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 8 summaries submitted
  • 3 summaries processed
Relative density at 20°C
0.876 - 0.98

Vapour pressure

Study results
  • 43 studies submitted
  • 31 studies processed
R Vapour pressure
71 - 58 484 Pa @ 19.9 - 100 °C [36]

Type of Study provided
Studies with data
Key study 41
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 8 summaries submitted
  • 3 summaries processed
Vapour pressure
1.86 - 100 hPa @ 20 °C

Partition coefficient

Study results
  • 15 studies submitted
  • 10 studies processed
R Log Pow
2.4 - 6.5 @ 21 - 25 °C and pH 6.2 - 7 [10]

Type of Study provided
Studies with data
Key study 11
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
R Summaries
  • 8 summaries submitted
  • 3 summaries processed
Log Kow (Log Pow)
2.13 - 5.8 @ 20 °C

Water solubility

Study results
  • 14 studies submitted
  • 5 studies processed
R Water solubility (mass/vol.)
33 - 108 mg/L @ 20 °C and pH 6.4 - 7.3 [5]

Type of Study provided
Studies with data
Key study 9
Supporting study 3
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
R Summaries
  • 8 summaries submitted
  • 3 summaries processed
Water solubility
20 - 1 880 mg/L @ 20 - 25 °C

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 7 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 3
Summaries
  • 4 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Flash point

Study results
  • 25 studies submitted
  • 23 studies processed
R Flash point
-30 - 145 °C @ 100.6 - 101.325 kPa [24]

Type of Study provided
Studies with data
Key study 23
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 6 summaries submitted
  • 1 summary processed
Flash point at 101 325 Pa
46.4 °C

Auto flammability

Study results
  • 12 studies submitted
  • 10 studies processed
R Autoflammability / self-ignition
220 - 505 °C @ 99.5 - 101.325 kPa [10]

Type of Study provided
Studies with data
Key study 10
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 6 summaries submitted
  • 1 summary processed
Autoflammability / self-ignition at 101 325 Pa
457 °C

Flammability

Study results
  • 7 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified 2
Exposure cons.
Other 3
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Flammability
Flammable (100%)

Explosiveness

Study results
  • 6 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other 4
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Oxidising

Study results
  • 6 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other 3
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 6 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 3
Sci. unjustified 2
Exposure cons.
Other 1
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Viscosity

Study results
  • 28 studies submitted
  • 25 studies processed
R Other:
1 - 29 [9]
R dynamic viscosity (in mPa s)
0.32 - 1 330 [10]
R kinematic viscosity (in mm²/s)
0.47 - 1 220 [22]

Type of Study provided
Studies with data
Key study 25
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 6 summaries submitted
  • 1 summary processed
Static viscosity at 20 °C
1.6 mm²/s

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Data not provided by the registrant

Hydrolysis

Study results
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 5
Exposure cons.
Other 1
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 18 studies submitted
  • 4 studies processed
C Interpretation of results
Inherently biodegradable (50%), Not readily biodegradable (25%), Under test conditions no biodegradation observed (25%) [4]

Type of Study provided
Studies with data
Key study 9
Supporting study 7
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
C Summaries
  • 8 summaries submitted
  • 4 summaries processed
Biodegradation in water
Under test conditions no biodegradation observed (75%), Readily biodegradable (25%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in soil

Study results
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 5
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: aquatic / sediment

Study results
  • 9 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 4
Supporting study 3
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
R Summaries
  • 6 summaries submitted
  • 1 summary processed
Bioaccumulation Factor (BCF) - dimensionless
162

Bioaccumulation: terrestrial

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Adsorption/desorption

Study results
  • 6 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 3
Summaries
  • 5 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Henrys law constant (H)

Data not provided by the registrant

Distribution modelling

Study results
  • 1 study submitted
  • 1 study processed
% Distribution in Media:
R Air 91.57 % [1]
R Water 1.54 % [1]
R Soil 4.82 % [1]
R Sediment 2.07 % [1]
R Suspended sediment 0.1 % [1]
R Biota 0.1 % [1]
R Aerosol 0.1 % [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers

No summary exists for this scientific endpoint

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 6 summaries submitted
  • 2 summaries processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 1 µg/L (1)
Intermittent releases (freshwater) No data available: testing technically not feasible (1)
Marine water 1 µg/L (1)
Intermittent releases (marine water) No data available: testing technically not feasible (1)
Sewage treatment plant (STP) No data available: testing technically not feasible (1)
Sediment (freshwater) No data available: testing technically not feasible (1)
Sediment (marine water) No data available: testing technically not feasible (1)
Hazard for Air
Air No hazard identified (2)
Hazard for Terrestrial Organism
Soil No data available: testing technically not feasible (1)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (1)

Short–term toxicity to fish

Study results
  • 28 studies submitted
  • 14 studies processed
P/RResults
LC50 (4 days) 580 - 8 410 µg/L [7]
NOEC (4 days) 5.6 mg/L [1]
LL50 (4 days) 730 - 48 000 µg/L [13]
LL50 (72 h) 2 - 5 mg/L [2]
LL50 (48 h) 2 - 54.4 mg/L [4]

Type of Study provided
Studies with data
Key study 14
Supporting study 11
Weight of evidence
Other 3
Data waiving
no waivers
R Summaries
  • 6 summaries submitted
  • 1 summary processed
LC50 for freshwater fish
730 µg/L

Long–term toxicity to fish

Study results
  • 6 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 4
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Short–term toxicity to aquatic invertebrates

Study results
  • 24 studies submitted
  • 13 studies processed
P/RResults
EC50 (48 h) 760 - 4 700 µg/L [8]
EC50 (24 h) 1.4 mg/L [2]
EL50 (48 h) 910 - 13 000 µg/L [11]
EL50 (24 h) 1.6 - 9.83 mg/L [5]
EL0 (48 h) 1 mg/L [1]

Type of Study provided
Studies with data
Key study 13
Supporting study 10
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 6 summaries submitted
  • 1 summary processed
EC50 / LC50 for freshwater invertebrates
910 µg/L
EC50 / LC50 for marine invertebrates
1.4 mg/L

Long–term toxicity to aquatic invertebrates

Study results
  • 6 studies submitted
  • 2 studies processed
P/RResults
EL50 (21 days) 810 - 890 µg/L [4]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 4
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Study results
  • 20 studies submitted
  • 9 studies processed
P/RResults
EC50 (4 days) 1 - 18.4 mg/L [3]
EC50 (72 h) 940 - 18 900 µg/L [3]
NOEC (4 days) 120 - 7 840 µg/L [5]
NOEC (72 h) 300 - 6 470 µg/L [6]
EL50 (72 h) 1 - 8.95 mg/L [4]

Type of Study provided
Studies with data
Key study 12
Supporting study 8
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 6 summaries submitted
  • 1 summary processed
EC50 for freshwater algae
1.3 mg/L
EC10 or NOEC for freshwater algae
460 µg/L

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 6 studies submitted
  • 3 studies processed
P/RResults
EC50 (3 h) 470 mg/L [1]
NOEC (56 days) 47.2 mg/L [1]
NOEC (28 days) 47.2 mg/L [1]
NOEC (5 days) 2 mg/L [1]
EC10 (3 h) 220 mg/L [1]

Type of Study provided
Studies with data
Key study 3 3
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 6 summaries submitted
  • 1 summary processed
EC10 or NOEC for microorganisms
47.2 mg/L

Sediment toxicity

Study results
  • 6 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 6
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 10 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 10
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial arthropods

Study results
  • 10 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 10
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial plants

Study results
  • 10 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 10
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to soil microorganisms

Study results
  • 6 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 6
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to birds

Study results
  • 6 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 6
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 8 summaries submitted
  • 5 summaries processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 2.31 mg/m³ repeated dose toxicity
Acute /short term: High hazard (no threshold derived)
Local Effects
Long-term: (DNEL) 2.31 mg/m³ irritation (respiratory tract)
Acute /short term: (DNEL) 160.23 mg/m³ irritation (respiratory tract)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 950 µg/kg bw/day repeated dose toxicity
Acute /short term: High hazard (no threshold derived)
Local Effects
Long-term: Low hazard (no threshold derived)
Acute /short term: Low hazard (no threshold derived)
EYE Exposure
Medium hazard (no threshold derived)
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 690 µg/m³ repeated dose toxicity
Acute /short term: Hazard unknown (no further information necessary as no exposure expected)
Local Effects
Long-term: (DNEL) 690 µg/m³ irritation (respiratory tract)
Acute /short term: (DNEL) 143.5 mg/m³ irritation (respiratory tract)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 280 µg/kg bw/day repeated dose toxicity
Acute /short term: Hazard unknown (no further information necessary as no exposure expected)
Local Effects
Long-term: Low hazard (no threshold derived)
Acute /short term: Low hazard (no threshold derived)
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 30 µg/kg bw/day repeated dose toxicity
Acute /short term: (DNEL) 25.6 mg/kg bw/day acute toxicity
EYE Exposure
Medium hazard (no threshold derived)

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 9 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other 3
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other
Study data: dermal absorption
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other
M/C Summaries
  • 7 summaries submitted
  • 3 summaries processed
Bioaccumulation potential:
Low bioaccumulation potential
Absorption values
Oral: 100 %
Dermal: 0.1 %
Inhalation: 50 %

Acute toxicity

Study results
oral
  • 39 studies submitted
  • 13 studies processed
P/RResults
LD50 512 - 5 000 mg/kg bw (rat) [15]
M/CInterpretations of results
Not classified [10]

Type of Study provided
oral
Studies with data
Key study 12 1
Supporting study 15 11
Weight of evidence
Other
Data waiving
no waivers
inhalation
  • 48 studies submitted
  • 15 studies processed
P/RResults
LC50 (7 h) 1.6 - 1.86 mg/L air (rat) [2]
LC50 (6 h) 1.723 mg/L air (rat) [1]
LC50 (6 h) 284 - 353 ppm (rat) [2]
LC50 (4 h) 2.7 - 30 000 mg/m³ air (rat) [19]
M/CInterpretations of results
Not classified [11]

inhalation
Studies with data
Key study 11 4
Supporting study 19 14
Weight of evidence
Other
Data waiving
no waivers
dermal
  • 35 studies submitted
  • 14 studies processed
P/RResults
LD50 2 000 mg/kg bw (rat) [4]
LD50 2 000 mg/kg bw (rabbit) [10]
M/CInterpretations of results
Not classified [10]

dermal
Studies with data
Key study 13 1
Supporting study 10 11
Weight of evidence
Other
Data waiving
no waivers
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 8 summaries submitted
  • 3 summaries processed
Oral route:
Adverse effect observed LD50 590 mg/kg bw
Inhalation route:
Adverse effect observed LC50 1 972 mg/m³
Dermal route:
No adverse effect observed LD50 2 000 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 60 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 18 6
Supporting study 17 17
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Study data: eye
  • 50 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 15 1
Supporting study 16 16
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
M/C Summaries
  • 8 summaries submitted
  • 7 summaries processed
Skin
Adverse effect observed (irritating)
Eye
Adverse effect observed (irritating)
Respiratory
Adverse effect observed (irritating)

Sensitisation

Study results
Study data: skin
  • 37 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 9 1
Supporting study 9 13
Weight of evidence
Other 3
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 8 summaries submitted
  • 7 summaries processed
Skin sensitisation
No adverse effect observed (not sensitising)
Respiratory sensitisation
No adverse effect observed (not sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 24 studies submitted
  • 14 studies processed
P/RResults
NOAEL (rat): 4 - 750 mg/kg bw/day [21]
LOAEL (rat): 25 - 1 250 mg/kg bw/day [10]

Type of Study provided
Study data: oral
Studies with data
Key study 8 6
Supporting study 3
Weight of evidence
Other 3
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 3
Study data: inhalation
  • 25 studies submitted
  • 17 studies processed
P/RResults
NOAEL (rat): 1 mg/L air [2]
NOAEL (mouse): 1 mg/L air [1]
LOAEL (rat): 500 mg/m³ air [2]
NOAEC (rat): 24 - 2 355 mg/m³ air [12]
NOAEC (rat): 30 - 625 ppm [12]

Study data: inhalation
Studies with data
Key study 8 9
Supporting study 4
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Study data: dermal
  • 35 studies submitted
  • 1 study processed
P/RResults
NOAEL (rat): 495 mg/kg bw/day [1]
LOEL (rat): 165 mg/kg bw/day [1]

Study data: dermal
Studies with data
Key study 1 1
Supporting study 8 15
Weight of evidence
Other 5
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other 3
M/C Summaries
  • 8 summaries submitted
  • 3 summaries processed
Oral route - systemic effects:
Adverse effect observed NOAEL 4 mg/kg bw/day (subacute, rat)
Dermal route - systemic effects:
No adverse effect observed NOAEL 495 mg/kg bw/day (subchronic, rat)
Dermal route - local effects:
Adverse effect observed LOAEL 1 mg/cm² (subchronic, rat)
Inhalation route - systemic effects:
No adverse effect observed NOAEC 1 000 mg/m³ (subchronic, rat)
Inhalation route - local effects:
No adverse effect observed NOAEC 1 000 mg/m³ (subchronic, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 36 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 13 8
Supporting study 4 9
Weight of evidence
Other 2
Data waiving
no waivers
Study data: in vivo
  • 27 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 11 5
Supporting study 2 9
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 8 summaries submitted
  • 2 summaries processed
Toxicity - InVivo
Adverse effect observed (positive)

Carcinogenicity

Study results
  • 33 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 10 7
Supporting study 2 6
Weight of evidence
Other 7
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
M/C Summaries
  • 8 summaries submitted
  • 1 summary processed
Oral route:
Adverse effect observed LOAEL 25 mg/kg bw/day (chronic, mouse)
Inhalation route:
Adverse effect observed LOAEC 960 mg/m³ (subchronic, mouse)

Toxicity to reproduction

Study results
Study data: reproduction
  • 22 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 6 1
Supporting study 3 4
Weight of evidence
Other 4
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other 1
Study data: developmental
  • 24 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 4 4
Supporting study 4 3
Weight of evidence
Other 7
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 8 summaries submitted
  • 2 summaries processed
Effect on fertility
Oral route:
No adverse effect observed NOAEL 1 500 mg/kg bw/day (subchronic, rat)
Dermal route:
No adverse effect observed NOAEL 494 mg/kg bw/day (subchronic, rat)
Inhalation route:
No adverse effect observed NOAEC 1 000 mg/m³ (subchronic, rat)
Effect on developmental toxicity
Oral route:
No adverse effect observed NOAEL 60 mg/kg bw/day (subacute, rat)

Neurotoxicity

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 6 summaries submitted
  • 1 summary processed
Inhalation route:
No adverse effect observed NOAEC 1 000 mg/m³ (subacute, rat)

Immunotoxicity

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Dermal route:
No adverse effect observed NOAEL 495 mg/kg bw/day (subacute, rat)

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant