Registration Dossier

Environmental fate & pathways

Bioaccumulation: aquatic / sediment

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

A measured BCF is not available for any streams in this category. As the log Kow of some category members is >3 the bioaccumulation endpoint cannot be waived. However, ECHA's Guidance on Information Requirements and Chemical Safety Assessment R7c Endpoint Specific Guidance (2008) indicates that before commissioning a new vertebrate test alternative sources of data on the bioaccumulation potential of a chemical should be used.

Non-polar substances have been shown to have a linear relationship between log Kow and BCF in the log Kow range 1 to 6. Several QSAR have been developed that calculate the BCF of non-polar, hydrophobic compounds on the basis of their log Kow (e.g. Veith et al, 1979 and USEPA, 2008). The method of Veith et al (1979) was used to calculate the BCF for representative substances of the streams since most of the substances fall within the applicability domain of the model.

The calculated BCF for representative components of the streams in this category are in the range 25.9-235.6 l/kg.

The mean of the BCF for the category is 150.1 l/kg and this has been used to complete the 'key value for chemical safety assessment'.

Key value for chemical safety assessment

BCF (aquatic species):
150.1 L/kg ww

Additional information