Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: other routes

Currently viewing:

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
Structure-Toxicity Relationship of Acrylic|Monomers.
Author:
Autian J
Year:
1975
Bibliographic source:
Environmental Health Perspectives 11: 141-152 [Review]
Reference Type:
publication
Title:
Development of a|Toxicity Evaluation Program for Dental Materials and|Products.
Author:
Lawrence WH, Malik M, Autian J
Year:
1974
Bibliographic source:
J. Biomed. Mat. Res. 8: 11-34

Materials and methods

GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Ethyl methacrylate
EC Number:
202-597-5
EC Name:
Ethyl methacrylate
Cas Number:
97-63-2
Molecular formula:
C6H10O2
IUPAC Name:
ethyl methacrylate
Details on test material:
ethyl methacrylate, purity: no data

Commercial source: Rohm & Haas Philadeliphia, Pa.
The substance contained from 5 to 2000 ppm of polymerization inhibitor, monomethyl ether of hydroquinone,
or 100 ppm hydroqunione. The monomer was used as such with no further purification. No more data available.

Test animals

Species:
mouse
Strain:
ICR
Sex:
male
Details on test animals or test system and environmental conditions:
The test animals were 25 +/- 5 gm, male albino ICR mice.

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
not specified
Details on study design:
 Several dose  levels of each compound were injected intraperitoneally into groups of  ten mice and the mice were observed for 7 days for mortality. Injections  were made with a clinical syringe when the dose to be 
administered was  greater than 1 ml. With a dose of 0.1 to 1.0 ml a tuberculin syringe was  used, and for doses of less than 0.1 ml a Hamilton microliter syringe was  used.
Statistics:
Acute LD50-values and 95 % confidence limits were calculated by Cornfield  and Mantel's modification of Karber's method.

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
1 247 mg/kg bw
Remarks on result:
other: Original value: 1.369 ml/kg equals 10.896 mol/10+6 gm (9.328 - 12.734  mol/10+6 gm) 95 % confidence limit) Density: 0.911 g/cm3

Applicant's summary and conclusion