Registration Dossier
Registration Dossier
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EC number: 202-597-5 | CAS number: 97-63-2
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Structure-Toxicity Relationship of Acrylic|Monomers.
- Author:
- Autian J
- Year:
- 1 975
- Bibliographic source:
- Environmental Health Perspectives 11: 141-152 [Review]
- Reference Type:
- publication
- Title:
- Development of a|Toxicity Evaluation Program for Dental Materials and|Products.
- Author:
- Lawrence WH, Malik M, Autian J
- Year:
- 1 974
- Bibliographic source:
- J. Biomed. Mat. Res. 8: 11-34
Materials and methods
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Ethyl methacrylate
- EC Number:
- 202-597-5
- EC Name:
- Ethyl methacrylate
- Cas Number:
- 97-63-2
- Molecular formula:
- C6H10O2
- IUPAC Name:
- ethyl methacrylate
- Details on test material:
- ethyl methacrylate, purity: no data
Commercial source: Rohm & Haas Philadeliphia, Pa.
The substance contained from 5 to 2000 ppm of polymerization inhibitor, monomethyl ether of hydroquinone,
or 100 ppm hydroqunione. The monomer was used as such with no further purification. No more data available.
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- ICR
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- The test animals were 25 +/- 5 gm, male albino ICR mice.
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- not specified
- Details on study design:
- Several dose levels of each compound were injected intraperitoneally into groups of ten mice and the mice were observed for 7 days for mortality. Injections were made with a clinical syringe when the dose to be
administered was greater than 1 ml. With a dose of 0.1 to 1.0 ml a tuberculin syringe was used, and for doses of less than 0.1 ml a Hamilton microliter syringe was used. - Statistics:
- Acute LD50-values and 95 % confidence limits were calculated by Cornfield and Mantel's modification of Karber's method.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 247 mg/kg bw
- Remarks on result:
- other: Original value: 1.369 ml/kg equals 10.896 mol/10+6 gm (9.328 - 12.734 mol/10+6 gm) 95 % confidence limit) Density: 0.911 g/cm3
Applicant's summary and conclusion
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