Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to microorganisms

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

Toxicity to microorganisms: 30-min EC50 1000-1800 mg/L (activated sludge)
The inhibition of the degradation activity of activated sludge is not anticipated when introduced in appropriate concentrations.

Key value for chemical safety assessment

EC50 for microorganisms:
1 000 mg/L

Additional information

Activated sludge inhibition data (ISO 8192) are available for ethyl methacrylate and indicate a 30-min EC50 of 1000 -1800 mg/L. Further MAA and the lower alkyl methacrylate category members up to the BMA isomers show a low toxicity to micro-organisms while for 2-EHMA no toxicity has been observed up to and above the limit of solubility. See the following table:

Summary of effects on micro-organisms







Pseudomonas putida

16h EC10= 100 mg/l

16 h growth inhibition test, sensitive species

Hanstveit, 1992


Pseudomonas putida

16h EC3= 100 mg/l

16 h growth inhibition test, sensitive species

Bringmann and Kühn, 1976, 1980ª


Activated sludge

14 d NOEC = 100 mg/l

Ready biodegradability test, OECD 310 C MITI (I)

CITI, 1992


Activated sludge

30 min EC50=
1000- 1800 mg/l

ISO8192 (OECD 209) respiration inhibition test

Hund and Fabig, 1989


Pseudomonas putida

18h EC10
253.6 mg/l

18 h growth inhibition test, sensitive species

Fabig and Hund, 1988


Pseudomonas fluorescens

16h EC10> 281 mg/l*

16 h growth inhibition test

Rump(Fresenius), 1988


Activated sludge

21 d NOEC = 100 mg/l

OECD 301 C

Modified MITI (I) Test

CERI, 1998b

* No growth inhibition with saturated solution