Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-597-5 | CAS number: 97-63-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- other: case reports
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- ethod and results sufficient described. Bias-positive: patients of dermatologists or dermal clinics are a cohort preselected for having a problem with the skin. Cross-reactions to other (meth)acrylates not suspended.
Data source
Reference
- Reference Type:
- publication
- Title:
- Occupational methacrylate and acrylate allergy from glues.
- Author:
- Aalto-Korte K, Alanko K, Kuuliala O, Jolanki R
- Year:
- 2 008
- Bibliographic source:
- Contact dermatitis Vol. 58, No. 6: 340-6
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- case report
- Principles of method if other than guideline:
- case reports, patch test
10 patients exposed to acrylic glues with occupational contact dermatitis examined during the years 1994 - 2006, sensitivity to acrylates and methacrylates were diagnosed. The patch tests were performed with (meth)acrylate series (Chemotechnique) using the Finn Chambers (Epitest, Tuusula, Finland) according to the recommendations of the International Contact Dermatitis Research Group. The tests were read 2 or 3 times on D2-(D3)-D4/5/6 depending on the day of their application. The test vehicle was petrolatum. - GLP compliance:
- not specified
Test material
- Reference substance name:
- Ethyl methacrylate
- EC Number:
- 202-597-5
- EC Name:
- Ethyl methacrylate
- Cas Number:
- 97-63-2
- Molecular formula:
- C6H10O2
- IUPAC Name:
- ethyl methacrylate
Constituent 1
Method
- Type of population:
- other: patients with dermatitis with previous contact with (meth)acrylate (acrylic glues)
- Subjects:
- - Number of subjects: 10 patients with suspected contact allergy were patch tested
- Route of administration:
- dermal
- Details on study design:
- A retrospective appraisal of 473 patch test records from September 1994 to August 2006 at the Finnish Institute of Occupational Health was made. 61 patients had allergic reactions to at least one allergen. Of these, 32 patients working in dental professions have been reported previously (Aalto-Korte k et al. (2007) Contact Dermatitis 57: 324-330). The files of 10 patients showed present occupational exposure to acrylic glues.
Results and discussion
- Results of examinations:
- 473 patients with a history of exposure to (meth)acrylates were identified. 39 (meth)acrylates were tested in 10 to 473 of these individuals. All 10 individuals showed at least one relevant reaction. For Ethyl methacrylate, 10 individuals were tested at a patch test concentration of 0.1 % in pet.(w/w). Of these 10 (occupationally exposed and sensitised to acrylic glues) individuals, 5 showed a positive reaction to EMA.
Applicant's summary and conclusion
- Conclusions:
- For Ethyl methacrylate, 10 individuals who had contact allergy to methacrylates or acrylates and had used acrylic glues at work were tested at a patch test concentration of 0.1 % (w/w) in petrolatum. Of these 10 individuals, 5 showed a positive reaction in respect of EMA.
- Executive summary:
For Ethyl methacrylate, 10 individuals who had contact allergy to methacrylates or acrylates and had used acrylic glues at work were tested at a patch test concentration of 0.1 % (w/w) in petrolatum. Of these 10 individuals, 5 showed a positive reaction in respect of EMA.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.