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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
other: data published
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Publication in scientific French journal, some details on study available which are sufficient for classification

Data source

Reference
Reference Type:
publication
Title:
Toxicites comparees des acides nitrobenzoiques pour la Souris et la Rat
Author:
F. Caujolle, D. Caujolle, C. Moisand
Year:
1966
Bibliographic source:
Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales, Vol 160, p. 1097-1100
Report Date:
1966

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
pre-guideline study
Test type:
other: no data available

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
Wistar
Sex:
female
Details on test animals and environmental conditions:
TEST ANIMALS

- Weight at study initiation: 200 to 220 g

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
physiological saline
Details on oral exposure:
concentration in vehicle: 10 %; sodium carbonate was added to achieve complete dissolution of the test substance. pH was adjusted to appr. 7.7 with hydrochloric acid.

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LD50
Effect level:
1 960 mg/kg bw
Based on:
test mat.
Gross pathology:
Effects on liver and spleen were traced.

Any other information on results incl. tables

No deaths were observed at 1410 mg/kg bw.

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information Criteria used for interpretation of results: expert judgment
Conclusions:
In an acute oral toxicity study a LD50 of 1960 mg/kg bw was determined. The substance has therefore to be classified:
Regulation (EC) 1272/2008: Acute toxicity (oral) category 4, H302 Harmful if swallowed
Directive 67/548/EEC, Harmful, R 22 Harmful if swallowed