Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-526-2 | CAS number: 62-23-7
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Limited documentation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 955
- Report date:
- 1955
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Company Guideline
- Principles of method if other than guideline:
- pre-guideline study. According to company guideline.
- GLP compliance:
- no
- Remarks:
- previous to GLP implementation
Test material
- Reference substance name:
- 4-nitrobenzoic acid
- EC Number:
- 200-526-2
- EC Name:
- 4-nitrobenzoic acid
- Cas Number:
- 62-23-7
- Molecular formula:
- C7H5NO4
- IUPAC Name:
- 4-nitrobenzoic acid
Constituent 1
Test animals
- Species:
- rat
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- 1 g/kg bw/day was administered to 5 rats 7 times within 9 days followed by a two day recovery period.
Doses / concentrations
- Remarks:
- Doses / Concentrations:
1 g/kg bw/day
Basis:
actual ingested
- No. of animals per sex per dose:
- 5 animals
Examinations
- Observations and examinations performed and frequency:
- HAEMATOLOGY: Yes, at the beginning and the end of the study
URINALYSIS: Yes, at the beginning and the end of the study - Sacrifice and pathology:
- GROSS PATHOLOGY: Yes
HISTOPATHOLOGY: Yes
Results and discussion
Results of examinations
- Clinical signs:
- not specified
- Mortality:
- not specified
- Body weight and weight changes:
- not specified
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- effects observed, treatment-related
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- no effects observed
- Behaviour (functional findings):
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Gross pathological findings:
- no effects observed
- Histopathological findings: non-neoplastic:
- no effects observed
- Histopathological findings: neoplastic:
- not specified
- Details on results:
- HAEMATOLOGY: 37 % decrease of erythrocytes and 26 % decrease of hemoglobin, formation of methemoglobin
No macroscopic and microscopic findings at necropsy.
Effect levels
- Dose descriptor:
- NOAEL
- Remarks:
- (limit test, effects were observed at the single dose tested)
- Effect level:
- >= 1 000 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- not specified
- Remarks on result:
- not determinable
- Remarks:
- no NOAEL identified
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
