Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-337-6 | CAS number: 119-61-9
Eye irritation
Administrative data
- Endpoint:
- eye irritation, other
- Remarks:
- in vivo study
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- Only results given (methodical details are missing)
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Several crystals of the compound were placed into the conjunctival sac of 6 rabbit eyes (3 rinsed/not rinsed each)
- GLP compliance:
- no
- Remarks:
- Data from 1980 (at this time GLP was not compulsory)
Test material
- Reference substance name:
- Benzophenone
- EC Number:
- 204-337-6
- EC Name:
- Benzophenone
- Cas Number:
- 119-61-9
- Molecular formula:
- C13H10O
- IUPAC Name:
- diphenylmethanone
- Details on test material:
- not further specified
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- not further specified
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- several crystals (not further specified)
- Duration of treatment / exposure:
- not further specified
- Observation period (in vivo):
- not further specified
- Number of animals or in vitro replicates:
- 6
Results and discussion
In vivo
Results
- Irritation parameter:
- other: The treatment caused only slight eye irritation in all animals.
- Remarks on result:
- probability of weak irritation
- Irritant / corrosive response data:
- The treatment caused only slight eye irritation in all animals.
Any other information on results incl. tables
The treatment caused only slight eye irritation in all animals.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The application of several crystals of benzophenone into the conjunctival sac of rabbits caused only a slight reaction.
- Executive summary:
In this study with rabbits the application of several crystals of benzophenone into the conjunctival sac (3 rinsed/not rinsed each) caused only a slight reaction. Thus benzophenone is not subject of classification.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
