Registration Dossier
Registration Dossier
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EC number: 201-939-0 | CAS number: 89-78-1
Endpoint summary
Administrative data
Description of key information
Hydrolysis
Data waiving:
In accordance with REACH Annex VIII column 2, the study does not need to be conducted if the substance is readily biodegradable.
Biodegradation
Ready biodegradability:
Read-across:
A closed bottle test comparable to OECD TG 301 D under aerobic conditions was performed and after 21 days a maximum percentage of 93 % biodegradation of L-Menthol (CAS no. 2216 -51 -5) was reached in a test with an initial concentration of 0.84 mg/L. 79 % of D-Menthol was degraded in a test with an initial concentration of 2.00 mg/L aftre 28 days. Therefore, L-Menthol is considered being readily biodegradable.
A closed bottle test comparable to OECD TG 301 D under aerobic conditions was performed and after 28 days 92 % of D-Menthol (CAS no. 15356-60-2) was degraded in a test with an initial concentration of 0.84 mg/L. 76 % of D-Menthol was degraded in a test with an initial concentration of 2.01 mg/L. Therefore, D-Menthol is considered being readily biodegradable.
Inherent biodegradability:
A test on inherent biodegradation comparable to OECD TG 302 B was performed with a duration of 5 days. 95.1 % of DL-Menthol was degraded during the test period. Therefore, DL-Menthol is considered being inherent biodegradable.
Bioaccumulation:
In a bioaccumulation test, corresponding to OECD Guideline 305C, a BCF of <0.5 - 15 at 0.2 mg/L and <4.6 - 11 at 0.02 mg/L test concentration for DL-Menthol was determined with Cyprinus carpio as test organism (15 - 20 animals/concentration) within 6 weeks.
Adsorption / desorption:
The QSAR determination of the carbon partition coefficient for DL-Menthol using the model KOCWIN included in the Estimation Program Interface (EPI) Suite v4.1 revealed values of 247.9 L/kg (logKow method) and 88.15 L/kg (MCI method) for the unaffected molecule of the substance as any decomposition (e.g. hydrolysis) of the substance is not taken into account by the program.
Additional information
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