Registration Dossier
Registration Dossier
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EC number: 487-120-0 | CAS number: 238098-26-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Adequacy of study:
- other information
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 92/69/EWG, B.1tris (Akute-toxische-Klassen-Methode)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test animals
- Species:
- other: rat, Wistar Hsd Cpb:WU
Administration / exposure
- Vehicle:
- corn oil
Results and discussion
Effect levels
- Sex:
- male/female
- Mortality:
- Female: 2000 mg/kg bw; Number of animals: 3; Number of deaths: 3
Female: 300 mg/kg bw; Number of animals: 3; Number of deaths: 0 - Clinical signs:
- other: Signs of toxicity related to dose levels: 2000 mg/kg bw, signs between 5 h and 4 d after administration: piloerection, decreased motility, reactivity decreased, uncoordinated gait, abdominal position, temporary tremor, labored breathing, narrowed p
- Gross pathology:
- Effects on organs:
In animals treated with 2000 mg/kg bw. that died during the
observation period the following changes were detected:
liver, discolorations, pale
The necropsies performed at the end of the study revealed n
particular findings in animals treated with 300 mg/kg bw.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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