Benzenamine, 2-methyl-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]-

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Adequacy of study:

other information

Data source

Reference

Reference Type:

other: Body responsible for the test

Title:

Unnamed

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: 92/69/EWG, B.1tris (Akute-toxische-Klassen-Methode)

GLP compliance:

yes

Test type:

standard acute method

Limit test:

no

Test animals

Species:

other: rat, Wistar Hsd Cpb:WU

Administration / exposure

Vehicle:

corn oil

Results and discussion

Effect levels

Sex:

male/female

Mortality:

Female: 2000 mg/kg bw; Number of animals: 3; Number of deaths: 3
Female: 300 mg/kg bw; Number of animals: 3; Number of deaths: 0

Clinical signs:

other: Signs of toxicity related to dose levels: 2000 mg/kg bw, signs between 5 h and 4 d after administration: piloerection, decreased motility, reactivity decreased, uncoordinated gait, abdominal position, temporary tremor, labored breathing, narrowed p

Gross pathology:

Effects on organs:
In animals treated with 2000 mg/kg bw. that died during the
observation period the following changes were detected:
liver, discolorations, pale


The necropsies performed at the end of the study revealed n
particular findings in animals treated with 300 mg/kg bw.

Applicant's summary and conclusion

Interpretation of results:

harmful

Remarks:

Migrated information Criteria used for interpretation of results: EU