Registration Dossier

Administrative data

Endpoint:
acute toxicity: dermal
Adequacy of study:
other information

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: 92/69/EWG, B.3
GLP compliance:
yes
Limit test:
yes

Test animals

Species:
other: rat, Wistar Hsd Cpb:WU

Administration / exposure

Type of coverage:
occlusive
Vehicle:
other: none
Duration of exposure:
24 h

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Mortality:
Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Clinical signs:
Signs of toxicity related to dose levels:
No signs were observed.
Gross pathology:
Effects on organs:
The necropsies performed at the end of the study revealed no
particular findings
Other findings:
Signs of toxicity (local):
No clinical signs were observed.

There were no toxicological effects on body weight or body
weight development in males and females.The decrease in body
weight gain of three females in the first week is assumed

to be caused by the stress of the application procedure, and
is not considered test compound related.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU