Registration Dossier

Administrative data

specific investigations: other studies
Adequacy of study:
other information

Data source

Reference Type:
other: Body responsible for the test

Materials and methods

Principles of method if other than guideline:
Test procedure:
OECD 429

Siehe Bemerkungen.

Results and discussion

Details on results:
Compared to vehicle treated animals none of the parameter
measured, i.e. cell counts and weights of the draining lymph
nodes, ear weights and ear swelling, reached or exceeded

the "positive levels" defined for this assay.

A slight significant increase compared to vehicle treated
animals regarding ear swelling was detected in the mid dose
group. No increase was determined for the ear weights in any
dose group.

The results show that the test item (RFA) has neither an
irritating nor a sensitizing potential in mice after dermal

Applicant's summary and conclusion